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Human Protein Reference Database (HPRD--http://www.hprd.org/), initially described in 2003, is a database of curated proteomic information pertaining to human proteins. We have recently added a number of new features in HPRD. These include PhosphoMotif Finder, which allows users to find the presence of over 320 experimentally verified phosphorylation motifs(More)
1 Institute of Bioinformatics, International Technology Park, Bangalore, Karnataka, India, 2 Manipal University, Manipal, Karnataka, India, 3 McKusick-Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland, United States of America, 4 The Lustgarten Foundation for Pancreatic Cancer(More)
Fibroblast growth factors (FGFs) are key regulators of cell proliferation, tumor-induced angiogenesis, and migration. FGFs are essential for early embryonic development, organ formation, and angiogenesis. FGF1 also plays an important role in inflammation, wound healing, and restenosis. The biological effects of FGF1 are mediated through the activation of(More)
IkappaB kinase (IKK), discovered as the major activator of NF-kappaB, plays additional roles in signaling. By using mouse embryo fibroblasts (MEFs) lacking both the alpha and beta subunits of IKK, we find that these proteins are required for induction of a major subset of IFNgamma-stimulated genes and that this requirement is independent of NF-kappaB(More)
Low-power wireless networks are an exciting research direction in sensing and widespread figuring out/calculating. Prior security work in this area has focused mostly on denial of communication at the routing or medium access control levels. This paper explores useful thing/valuable supply using everything up (completely) attacks at the routing rules of(More)
Data mining techniques are used to discover hidden information from large databases. Among many data mining techniques, association rule mining is receiving more attention to the researchers to find correlations between items or items sets efficiently. In distributed database environment, the way the data is distributed plays an important role in the(More)
Availability of a freely accessible, dynamic and integrated database for primary immunodeficiency diseases (PID) is important both for researchers as well as clinicians. To build a PID informational platform and also as a part of action to initiate a network of PID research in Asia, we have constructed a web-based compendium of molecular alterations in PID,(More)
Back ground: Periodontitis is a chronic inflammatory disease, causes changes in peripheral blood markers with slight abnormal lipid profile including the production of different enzymes that are released by stromal, epithelial or inflammatory cells. These changes reflect metabolic changes in the gingival and periodontium in inflammation. Design of study:(More)
S100A13 and acidic fibroblast growth factor (FGF1) are involved in a wide array of important biological processes, such as angiogenesis, cell differentiation, neurogenesis, and tumor growth. Generally, the biological function of FGF1 is to recognize a specific tyrosine kinase on the cell surface and initiate the cell signal transduction cascade. Amlexanox(More)