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Human Protein Reference Database (HPRD--http://www.hprd.org/), initially described in 2003, is a database of curated proteomic information pertaining to human proteins. We have recently added a number of new features in HPRD. These include PhosphoMotif Finder, which allows users to find the presence of over 320 experimentally verified phosphorylation motifs(More)
BACKGROUND MicroRNAs (miRNAs) are increasingly being recognized as being involved in cancer development and progression in gliomas. METHODS Using a model cell system developed in our lab to study glioma progression comprising human neuroglial culture (HNGC)-1 and HNGC-2 cells, we report here that miR-145 is one of the miRNAs significantly downregulated(More)
Although there is intense activity towards identifying novel biomarkers for cancers, especially those for early detection , it is not clear whether we already have too many biomarkers described in the literature. Given that there is no central repository of data pertaining to any cancer, it is difficult to estimate if we have too many proteins described as(More)
Many data mining techniques are available to explore useful hidden information from large databases. Among these, association rule mining has wide applications to discover interesting relationships among attributes. The issue of privacy arises when the data is distributed among multiple sites and no site owner wishes to provide their private data to other(More)
MiRNA-34a is considered as a potential prognostic marker for glioma, as studies suggest that its expression negatively correlates with patient survival in grade III and IV glial tumors. Here, we show that expression of miR-34a was decreased in a graded manner in glioma and glioma stem cell-lines as compared to normal brain tissues. Ectopic expression of(More)
— Data mining techniques are used to discover hidden information from large databases. Among many data mining techniques, association rule mining is receiving more attention to the researchers to find correlations between items or items sets efficiently. In distributed database environment, the way the data is distributed plays an important role in the(More)
Availability of a freely accessible, dynamic and integrated database for primary immunodeficiency diseases (PID) is important both for researchers as well as clinicians. To build a PID informational platform and also as a part of action to initiate a network of PID research in Asia, we have constructed a web-based compendium of molecular alterations in PID,(More)
— Low-power wireless networks are an exciting research direction in sensing and widespread figuring out/calculating. Prior security work in this area has focused mostly on denial of communication at the routing or medium access control levels. This paper explores useful thing/valuable supply using everything up (completely) attacks at the routing rules of(More)
Data mining techniques are useful to discover hidden patterns from the large databases. Association rule mining is one of the important data mining techniques to discover relationships between items or item sets. In many organizations the database may exist in centralized or in distributed environment. In distributed environment, database may be partitioned(More)