Sandhya A. Lagoo-Deenadayalan

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The present guidelines are the most recent data on postoperative nausea and vomiting (PONV) and an update on the 2 previous sets of guidelines published in 2003 and 2007. These guidelines were compiled by a multidisciplinary international panel of individuals with interest and expertise in PONV under the auspices of the Society for Ambulatory Anesthesia.(More)
BACKGROUND Because of the aging United States population, increase in overall life expectancy, and rising incidence of hepatobiliary tumors, more elderly patients are considered for hepatic resection. The objective of this study was to assess the influence of age on postoperative outcomes after major hepatectomy among a contemporary cohort from 2 high(More)
PROBLEM Cytokines form an important communication network between the mother and fetus. Defining the significance of these factors requires an understanding of their constitutive expression by maternal and fetal tissues. This study examines cytokine expression by human trophoblast. METHODS A reverse transcription polymerase chain reaction (RT-PCR)(More)
OBJECTIVE To determine if increasing nitric oxide bioactivity by inclusion of ethyl nitrite (ENO) in the insufflation admixture would attenuate pneumoperitoneum-induced decreases in splanchnic perfusion. SUMMARY BACKGROUND DATA Organ blood flow is reduced during pneumoperitoneum and can contribute to laparoscopy-associated morbidity and mortality.(More)
OBJECTIVE To examine the de novo synthesis and cellular distribution of the E-selectin adhesion molecule in synovial tissues obtained from patients with rheumatoid arthritis (RA). METHODS Immunohistochemistry techniques combined with in situ hybridization were used to examine RA synovium. RESULTS There were numerous endothelial cells positive for(More)
Initial exposure of monocytes/macrophages to LPS induces hyporesponsiveness to a second challenge with LPS, a phenomenon termed LPS tolerance. Molecular mechanisms responsible for endotoxin tolerance are not well defined. We and others have shown that IL-1R-associated kinase (IRAK)-M and SHIP-1 proteins, negative regulators of TLR4 signaling, increase in(More)
OBJECTIVE We sought to determine whether placental cytokine expression is altered in patients with preeclampsia. STUDY DESIGN Whole placental tissue was collected at cesarean delivery, and total ribonucleic acid was extracted. Reverse transcriptase-polymerase chain reaction was performed to determine cytokine expression. Product bands were quantitated by(More)
A simple, rapid, reproducible, and nonradioisotopic method for semiquantitative analysis of cytokine mRNAs based on polymerase chain reaction (PCR) is described. RNA isolated from 2.5 million cells has proven sufficient to perform semiquantitative analysis of mRNA for 10 different cytokines. By this approach accurate assessment of mRNA levels for multiple(More)
OBJECTIVES To determine whether readily collected perioperative information might identify older surgical patients at higher risk of complications. DESIGN Retrospective cohort study. SETTING Medical chart review at a single academic institution. PARTICIPANTS One hundred two individuals aged 65 and older who underwent abdominal surgery between January(More)