Sander Steeghs

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Fibrous polyurethane (FPU) prostheses with or without fibronectin coating and gelatin impregnation and FPU prostheses with or without fibronectin coating were seeded with 4.8 x 10(5) subcultivated dog endothelial cells per cm2 prosthesis. Expanded polytetrafluoroethylene (ePTFE) prostheses with and without fibronectin coating served as controls. The numbers(More)
Expanded polytetrafluoroethylene (PTFE) prostheses with fibril lengths of 30 and 60 microns were implanted in the rat infrarenal aorta. Sequential scanning electron and light microscopic studies of the prostheses after implantation demonstrated a different pattern of endothelialization. Prostheses with a fibril length of 60 microns had a continuous(More)
Patency of vascular prostheses implanted in the rat aorta is usually confirmed by reoperation and inspection of the distal stump of the aorta for pulsations. Repeated reoperation on rats included in long-term investigations is not possible because of the increasing formation of scar tissue and adhesions at the site of the distal aorta. Consequently,(More)
Autonomous driving technology is evolving quickly, and self-driving cars are fast becoming a reality. In the level 2 autonomous driving stage, the system will take full control of the vehicle. The driver must monitor the driving and be prepared to immediately intervene at any time if the automated system fails to respond properly. As a result, the vehicle(More)
The development and long-term fate of the inner cellular lining in 72 small caliber (3 mm inner diameter) fibrous polyurethane vascular prostheses explanted from dog carotid and/or femoral arteries at times ranging from 1.5 weeks up to 53 months after implantation were studied by scanning electron and light microscopy. A continuous cellular ingrowth from(More)
A new type of vascular prosthesis made of polyurethane with a fibrous structure of the wall was implanted in the carotid and/or femoral artery of dogs. The healing process and neo-intima formation after implantation of this type of prosthesis was followed with light- and scanning electron microscopy. A total of 18 prostheses, which had been implanted for 1,(More)
A cell culture line was established from enzymatically-derived canine jugular endothelial cells and further cultured. Whenever sufficient cells were present, fibrous polyurethane vascular prostheses, impregnated with gelatin and coated with fibronectin, were seeded with 4.8 x 10(5)/cm2 cells, sufficient to establish a confluent monolayer, and implanted in(More)
Fibrous polyurethane prostheses were implanted in the carotid arteries and aortae of New Zealand white (NZW) and Chinchilla (CHIN) rabbits. No immediate post-implantation patency was obtained after implantation in the carotid arteries in NZW rabbits. In CHIN rabbits patency up to 1 week was obtained after carotid implantation. Attempts to increase patency(More)
In a preliminary experiment externally reinforced polyurethane prostheses measuring 20 cm in length, with an inner diameter of 3 mm, were implanted in a loop in the femoral artery of six dogs. The dogs received 250 mg acetylsalicylic acid and 25 mg dipyridamol three times a day as anti-thrombocyte aggregation therapy starting three weeks prior to surgery.(More)
Segments of 3 mm diameter fibrous polyurethane vascular prosthesis of length 3-4 cm were prepared. They were bilaterally implanted in the carotid and femoral arteries of male and female beagles. Four groups consisting of animals receiving either no medication or thrombocyte aggregation drugs were studied: Group A (8 dogs), no medication: group B (19 dogs),(More)
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