Sander Meijer

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The physiology of Aspergillus niger was studied under different aeration conditions. Five different aeration rates were investigated in batch cultivations of A. niger grown on xylose. Biomass, intra- and extra-cellular metabolites profiles were determined and ten different enzyme activities in the central carbon metabolism were assessed. The focus was on(More)
Shock tube experiments and simulations are conducted with a spherical gelatin filled skull-brain surrogate, in order to study the mechanisms leading to blast induced mild traumatic brain injury. A shock tube including sensor system is optimized to simulate realistic improvised explosive device blast profiles obtained from full scale field tests. The(More)
In order to improve the production of succinate and malate by the filamentous fungus Aspergillus niger the activity of the glyoxylate bypass pathway was increased by over-expression of the isocitrate lyase (icl) gene. The hypothesis was that when isocitrate lyase was up-regulated the flux towards glyoxylate would increase, leading to excess formation of(More)
Lysophosphatidic acid (LPA) is a novel phospholipid mediator with diverse biological activities such as smooth muscle contraction, and proliferative effects or modifications of cytoskeleton. Activated blood platelets are the best identified source, explaining accumulation of LPA in serum upon blood coagulation. However, the metabolic pathways responsible(More)
The Dutch governmental Sociale Verzekeringsbank (SVB) recently completed a project on business modeling. The aim was to develop business models that express the strategic goals of customer event orientation, integrated customer services as well as improved agility. An approach was chosen to combine event definition, dynamic process modeling and business(More)
Different diagnostic techniques are currently available for on-line insulation condition assessment of power transformers. Amongst these techniques a relatively new technique for detecting partial discharges (PD) in the Ultra High Frequency range of the spectrum is also introduced. The UHF technique has been recently presented in the field of transformer(More)
<lb>The Dutch governmental Sociale Verzekeringsbank (SVB) recently completed a project<lb>on business modelling. The aim was to develop business models that express the<lb>strategic goals of customer event orientation, integrated customer services, as well as<lb>improved agility. An approach was chosen to combine event definition, dynamic<lb>process(More)
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