Sandeep Saxena

Aparna Sharma3
Ananya Kar3
Md. Muntaz Khan2
3Aparna Sharma
3Ananya Kar
2Md. Muntaz Khan
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When mammalian cells experience radiation insult, DNA replication is stalled to prevent erroneous DNA synthesis. UV-irradiation triggers proteolysis of Mcm10, an essential human replication factor, inhibiting the ongoing replication. Here, we report that Mcm10 associates with E3 ubiquitin ligase comprising DNA damage-binding protein, DDB1, cullin, Cul4 and(More)
  • Sumana Chakravarty, Bommana R. Reddy, Sreesha R. Sudhakar, Sandeep Saxena, Tapatee Das, Vuppalapaty Meghah +3 others
  • 2013
Anxiety and depression are major chronic mood disorders, and the etiopathology for each appears to be repeated exposure to diverse unpredictable stress factors. Most of the studies on anxiety and related mood disorders are performed in rodents, and a good model is chronic unpredictable stress (CUS). In this study, we have attempted to understand the(More)
BACKGROUND Mcm10 protein is essential for initiation and elongation phases of replication. Human cells proteolyze Mcm10 during mitosis, presumably to ensure a single round of replication. It has been proposed that anaphase promoting complex ubiquitinates Mcm10 in late M and early G1 phases. RESULTS In contrast to the previous work, we report that the(More)
Cloud computing become more popular in every field of life nowadays. This happened only due to its amazing services that provide to clients in the form of everything-as-a-service(XaaS). Where at one side cloud computing is gaining popularity and another side its faces some issues i.e. security issue, total cost issue, energy consumption issue, performance(More)
Cloud computing is a type of grid computing which is a form of distributed computing and distributed computing is a special type of parallel computing. Presently a lot of services are growing under the single umbrella that is known as cloud computing. Cloud computing gain popularity in the several area due its property of everything-as-a-service(XaaS),(More)
Spectral domain optical coherence tomography cross-sectional imaging of the macula has conventionally been resolved into four bands. However, some doubts were raised regarding authentication of the existence of these bands. Recently, a number of studies have suggested that the second band appeared to originate from the inner segment ellipsoids of the foveal(More)
Astrocytic hamartomas are rare benign tumours. Spectral domain optical coherence tomography (SD-OCT) with advanced visualisation (optic disc cube 200×200) was performed on a 27-year-old man with peripapillary astrocytic hamartomas in the right eye. En face (OCT scan) view (CT scan) of the optic nerve at the level of retinal pigment epithelium revealed optic(More)
The primary eukaryotic single-stranded DNA-binding protein, Replication protein A (RPA), binds to single-stranded DNA at the sites of DNA damage and recruits the apical checkpoint kinase, ATR via its partner protein, ATRIP. It has been demonstrated that absence of RPA incapacitates the ATR-mediated checkpoint response. We report that in the absence of RPA,(More)
Three-dimensional spectral domain optical coherence tomography was performed in a 26-year-old man with chronic exposure to welding arc. Advanced macular visualisation provided significant findings of inner segment-ellipsoid zone disruption with the presence of cystoid changes and hyper-reflective material in the area of disruption. The external limiting(More)