Sandeep Ramachandra Pai

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The observations on the effect of 3 agents--1,4-dinitrosopiperazine, betel nut and saccharin fed to C17 mice in combination is presented in this report. A total of 119 inbred mice of both sexes were put on long-term feeding trials. Group I consisted of 34 mice given a standard diet; group II of 32 mice fed an experimental diet containing saccharin coated(More)
Effects of varying temperatures with constant pressure of solvent on extraction efficiency of two chemically different alkaloids were studied. Camptothecin (CPT) from stem of Nothapodytes nimmoniana (Grah.) Mabb. and piperine from the fruits of Piper nigrum L. were extracted using Accelerated Solvent Extractor (ASE). Three cycles of extraction for a(More)
The magnitudes of several pools of radioactively labeled precursors for RNA and protein synthesis were determined as a function of cell age during the division cycle of Escherichia coli 15 THU. Uracil, histidine, and methionine pools increased from low initial values for cells at birth to maxima during midcycle and then subsided again. These pools were(More)
Methods are described for measuring soluble pool magnitudes in steady-state or exponentially growing cultures, and for distinguishing between anabolic, catabolic and total metabolic pools within cells. These methods were applied to the measurement of pool magnitudes for several amino acids and other precursors in Escherichia coli THU. Our results support(More)
ATTENTION to the mastomys [Rattus natalensis, Praomis natalensis (Davis, 1965; Snell and Stewart, 1967), multimammate mouse (Oettle, 1961)] as a useful species for investigations on the etiology of cancer was drawn first by the late Dr. Oettle (1955, 1957) who observed that older mastomys exhibited spontaneous gastric adenocarcinoma. These findings were(More)
Reliable and reproducible techniques for identification and quantification of amino acids usually require derivatization. However, techniques such as LC-MS/MS may perhaps sideline the derivatization with significant accuracy. Understanding the interaction between free amino acids and several physiological processes apparently requires that the pool be(More)
BACKGROUND Achyranthes coynei Sant. (Family: Amaranthaceae) is a rare endemic medicinal plant used by local traditional practitioners to treat various diseases. The plant has been reported for promising antibacterial and antioxidant activities. However, the plant is not explored for its phytocompounds, especially triterpenoids. OBJECTIVE TO STUDY THE(More)