Sandeep Raghuwanshi

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CXCL8 (also known as IL-8) activates CXCR1 and CXCR2 to mediate neutrophil recruitment and trigger cytotoxic effect at sites of infection. Under physiological conditions, CXCL8 could exist as monomers, dimers, or a mixture of monomers and dimers. Therefore, both forms of CXCL8 could interact with CXCR1 and CXCR2 with different affinities and potencies to(More)
The chemokine receptors, CXCR1 and CXCR2, couple to Gαi to induce leukocyte recruitment and activation at sites of inflammation. Upon activation by CXCL8, these receptors become phosphorylated, desensitized, and internalized. In this study, we investigated the role of different G protein-coupled receptor kinases (GRKs) in CXCR1- and CXCR2-mediated cellular(More)
Endoplasmic reticulum (ER) stress triggers a homeostatic cellular response in mammalian cells to ensure efficient folding , sorting, and processing of client proteins. In lytic-permissive lymphoblastoid cell lines (LCLs), pulse exposure to the chemical ER-stress inducer thapsigargin (TG) followed by recovery resulted in the activation of the EBV(More)
Cloud computing is a developing computing paradigm that has inclined every other entity in the digital industry, it may be government sector or the personal sector. Taking into account the mounting significance of cloud, finding new ways to advance cloud services is an area of concern and research center. Usually clouds have powerful data centers to handle(More)
A mobile ad hoc network is a collection of autonomous mobile nodes that communicate with each other over wireless links. Such networks are expected to play increasingly important role in future civilian and military settings, being useful for providing communication support where no fixed infrastructure exists or the deployment of a fixed infrastructure is(More)
— Wireless networks are gaining popularity to its peak nowadays, the desire to be connected anytime and anywhere has led to the development of wireless network, opening new vista of research in pervasive and ubiquitous computing. Mobile Ad hoc Network (MANET) has distributed mobile wireless nodes, which do not have predetermine topology and pre-existing(More)
Two parties that conduct a business transaction through the internet do not see each other face-to-face nor do they exchange any document or currency hand-to-hand. Electronic payment is a way by which the two parties transfer the money through internet. Offering electronic payment can also help businesses improve and customer retention. When electronic(More)
Security is one of the major issues in Mobile Ad-hoc Network (MANET) because of its inherent liabilities. Its infrastructure-less network with dynamic topology pose a number of challenges to security design and makes it vulnerable for different types of security attacks. In wormhole attack a pair of colluding nodes makes a tunnel using a high speed network.(More)
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