Sandeep Khanna

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Patients with advanced gastrointestinal and pelvic malignancies commonly present with pain of varying severity. In a majority of these patients, pain can be effectively managed using an integrated systemic pharmacological approach with oral morphine being the cornerstone of treatment. However, with escalating doses, intolerable side effects of oral morphine(More)
Three patients underwent stereotactic posteroventral pallidotomy, and 1 patient underwent pallidal deep brain stimulation, for medically intractable symptoms of advanced Parkinson's disease, characterized by peak-dose levodopa dyskinesias, wearing-off fluctuations, tremor, rigidity and bradykinesia. Surgery was performed stereotactically under local(More)
OBJECTIVE To determine the incidence of vasospasm in children who have suffered moderate to severe traumatic brain injury. METHODS A prospective observational pilot study in a 24-bed pediatric intensive care unit was performed. Twenty-two children aged 7 months to 14 years with moderate to severe traumatic brain injury as indicated by Glasgow Coma Score(More)
In neuroscience research, the use of true single-unit microelectrode technique has been confined largely to the animal neurophysiology laboratory due to the complexity of the equipment required and the fastidious, time-consuming nature of the methodology. We report here our successful clinical use of this technique in human patients with Parkinson's disease(More)
The traditional ASIC netlist handoff is changing-but to what? Is RTL handoff finally a reality? Or, will a placement-based handoff model emerge? Are differences among underlying tool technologies and methodologies only cosmetic? Or, are there fundamental business and IP distinctions? These and other questions will be discussed as the panel examines the(More)
BACKGROUND A variety of radiologic screening protocols exist for evaluation of pediatric trauma patients with potential cervical spine (c-spine) injuries. The purpose of this study was to describe findings on c-spine magnetic resonance imaging (MRI) after previously normal c-spine computed tomographic (CT) scan findings at a Level 1 trauma center. METHODS(More)
BACKGROUND Cancer pain is often intractable and has a considerable impact on the quality of life. Nociceptive pain is easily recognized and managed using conventional analgesics. The neuropathic component makes cancer pain difficult to manage. The epidemiology of neuropathic pain in cancer patients has not been well documented. AIM OF THE STUDY This(More)
OBJECTIVE Dexmedetomidine (DEX; Precedex) is an alpha-2 adrenergic receptor agonist that produces anxiolysis and sleep-like sedation without narcosis or respiratory depression and has relatively few cardiovascular side effects. Given its favorable sedative properties combined with its limited effects on hemodynamic and respiratory function, it is widely(More)
The traditional ASIC netlist handoff is changing - but to what? Is RTL handoff finally a reality? Or, will a placement-based handoff model emerge? Are differences among underlying tool technologies and methodologies only cosmetic? Or, are there fundamental business and IP distinctions? These and other questions will be discussed as the panel examines the(More)
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