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Haemopoiesis in mammals takes place in yolk-sac and in mouse it can be detected on the 7th day of gestation. Erythropoietin (EPO) responsive cells can be detected from 7th day onwards. However, the cells committed to the myeloid lineage which can respond to the haemopoietic growth factor (viz. granulocyte macrophage colony stimulating factor; GM-CSF) can be… (More)
The haematopoietic microenvironment which is provided by the stromal cells and extracellular matrix elements has been shown to influence the growth and differentiation of haematopoietic cells. However, most of the information thus far available has been derived from experiments performed using Long Term Bone Marrow Cultures and there is as yet no… (More)
In this paper the probable mechanism of the haemopoietic pluripotent stem cell (PSC) homing into the bone-marrow is investigated. Experiments were done to understand the role of fibronectin hexapeptide and ubiquitin. Attempts to isolate the PSC adherence molecule were made. A new adherence assay for PSC has been described.