Expression patterns of the 11 potential biomarkers of prenatal arsenic exposure. Absolute gene expresion levels are plotted versus toenail arsenic concentration. Circles represent each of the 32 subjects of the population with light blue representing the arsenic unexposed subjects and dark blue representing the arsenic exposed subjects.
The long-term health outcome of prenatal exposure to arsenic has been associated with increased mortality in human populations. In this study, the extent to which maternal arsenic exposure impacts gene expression in the newborn was addressed. We monitored gene expression profiles in a population of newborns whose mothers experienced varying levels of… (More)
There is considerable heterogeneity in immunological parameters between individuals, but its sources are largely unknown. To assess the relative contribution of heritable versus non-heritable factors, we have performed a systems-level analysis of 210 healthy twins between 8 and 82 years of age. We measured 204 different parameters, including cell population… (More)
To date, our understanding of a normal immune system is far behind that of other healthy organ systems. One reason for this is the lack of standardization in the lab techniques, especially flow cytometry. To take a step towards the characterization of a normal immune system, we re-analyzed and combined data that was made publicly available through the… (More)
OBJECTIVE Cytokines play a central role in both health and disease, modulating immune responses and acting as diagnostic markers and therapeutic targets. This work takes a systems-level approach for integration and examination of immune patterns, such as cytokine gene expression with information from biomedical literature, and applies it in the context of… (More)
Data generated by the numerous clinical trials conducted annually worldwide have the potential to be extremely beneficial to the scientific and patient communities. This potential is well recognized and efforts are being made to encourage the release of raw patient-level data from these trials to the public. The issue of sharing clinical trial data has… (More)
Broad open access to entire clinical research studies data is on the rise. Public access to raw clinical research data has created tremendous opportunity to evaluate new research hypotheses that were not originally formulated in the studies; by reanalyzing data from a study, by performing cross analysis of multiple studies, or by combining study data with… (More)
Studies have shown a large number of immune related diseases, in particular auto-immune diseases, to have a genetic component. The immune system is dependent on the functionality of a multitude of components, key factors of which are the different immune cell-type subsets and the cytokines to which they respond to or secrete. However, the abundance of… (More)