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The imprinted, developmentally regulated H19 long noncoding RNA has been implicated in the pathogenesis of diverse human cancers, but the underlying mechanisms have remained poorly understood. Here, we report that H19 promotes tumor cell migration and invasion by inhibiting let-7, a potent tumor suppressor microRNA that functions to posttranscriptionally(More)
Endometriosis affects approximately 15% of reproductive aged women and is associated with chronic pelvic pain and infertility. However, the molecular mechanisms by which endometriosis impacts fertility are poorly understood. The developmentally regulated, imprinted H19 long noncoding RNA (lncRNA) functions to reduce the bioavailability of microRNA let-7 by(More)
This work examined the trend in “embryo wastage” rates after ART in USA and its relationship to the number of embryos transferred, live born infants delivered across patient age, and the yearly percentage of embryos wasted. The data were obtained from the US-clinics SART databank for the years 2004–2013. A total of 1,808,082 non-donor embryos were(More)
Nasal carriage of Staphylococcus aureus is a sensitive indicator of staphylococcal col-onization and is considered a source of subsequent infection. When the incidence of S. au-reus colonization increased in our neonatal intensive care unit (NICU), resulting in three methicillin-resistant Staphylococcus aureus (MRSA) infections over a three-month period, we(More)
PURPOSE OF REVIEW Germline stem cell research over the last decade has brought into question one of the basic tenets of reproductive biology that women are born with a finite number of oocytes without the potential for renewal. Evidence for the existence of oogonial stem cells in the postnatal ovary has gained momentum, but skepticism remains. RECENT(More)
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