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The structure of a central component of the eukaryotic transcriptional apparatus, a TATA-box binding protein (TBP or TFIID tau) from Arabidopsis thaliana, has been determined by X-ray crystallography at 2.6 A resolution. This highly symmetric alpha/beta structure contains a new DNA-binding fold, resembling a molecular 'saddle' that sits astride the DNA. The(More)
Many protein kinases are self-regulated by an intrasteric mechanism where part of the enzyme's structure directly inhibits the active site. This inhibitory structure is called a pseudosubstrate and specific regulators are required to remove it from the active site to allow substrates access. Removal of the pseudosubstrate sequence from members of the myosin(More)
Herein, we present a complete three-dimensional (3D) map of major neuropil structures in the central brain of the cockroach Diploptera punctata. The positions of the structures have been ascertained by confocal microscopy, which, until now-for reasons of tissue opacity and nonhomogeneity-has been thought impractical in imaging fluorescently labeled(More)
OBJECTIVE The aim of this study was to investigate the possible microstructural abnormalities of the corpus callosum (CC) in adult patients with migraine without aura complicated with depressive/anxious disorder. BACKGROUND Emotional disorders, especially depression and anxiety, are with relatively higher incidence in migraine population. However, the(More)
  • Bao-Gang Hu, S.-Y Qing, B.-G Hu, Li, S Gomiz, M Jaeger +17 others
  • 2009
A generalized constraint neural networks model: Associating partially known relationships for nonlinear regressions " , Analytical study of a stochastic plant growth model: Application to the GreenLab model " , An adaptive fuzzy c-means clustering-based mixtures of experts model for unlabeled data classification " ,
Conotoxins are valuable probes of receptors and ion channels because of their small size and highly selective activity. alpha-Conotoxin EpI, a 16-residue peptide from the mollusk-hunting Conus episcopatus, has the amino acid sequence GCCSDPRCNMNNPDY(SO3H)C-NH2 and appears to be an extremely potent and selective inhibitor of the alpha3beta2 and alpha3beta4(More)
OBJECTIVES. To study the efficacy and associated serum prolactin levels of ziprasidone and olanzapine treatment in drug-naïve schizophrenia patients. METHODS. All 78 inpatients with drug-naïve schizophrenia were recruited from the Department of Psychology, The Third Affiliated Hospital of Sun Yat-sen University. They were divided into either olanzapine(More)
Individuals carrying mutations at both ataxia telangiectasia mutated (ATM) gene alleles reportedly have increased plasma cholesterol and triglyceride levels. Previous studies have demonstrated that defective ATM function promotes atherosclerosis. We previously demonstrated that ATM facilitates the clearance of plasma apolipoprotein (Apo)E-deficient,(More)
In this paper, we go on to investigate the concave Young function inequalities for N-demimartingales and obtain some maximal type inequalities for these stochastic process. As some specific concave Young functions, some related inequalities for N-demimartingales are presented. Meanwhile, some convex function inequalities for nonnegative N-demimartingales(More)
This review highlights significant biological psychiatric research published by Chinese researchers in recent years. Chinese periodicals with full-text database (Chinese National Knowledge Infrastructure) and English periodicals with PubMed, published from 2003 to 2009 on schizophrenia, depression, bipolar affective disorder, obsessive-compulsive disorder,(More)