Samuele Bovo

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In this paper, a partitioning approach for large-scale systems based on graph-theory is presented. The algorithm starts with the translation of the system model into a graph representation. Once the system graph is obtained, the problem of graph partitioning is then solved. The resultant partition consists in a set of non-overlapping subgraphs whose number(More)
Abstract: In this paper, the application of decentralised model predictive control (DMPC) over a partitioned model of the Barcelona drinking water network (DWN) is proposed. The system decomposition is based on graph partitioning theory, which considers the graph representation of the DWN topology. Once obtained, this system decomposition yields to some(More)
Background: Insulin-like growth factor 2 (IGF2) is a key regulator of skeletal myogenesis during developmental stages and is involved in many other growth-related processes and several diseases. The important biological role of IGF2 is highlighted by the complexity of its gene regulation, which is based on epigenetic mechanisms that preferentially determine(More)
MOTIVATION Gene enrichment is a requisite for the interpretation of biological complexity related to specific molecular pathways and biological processes. Furthermore, when interpreting NGS data and human variations, including those related to pathologies, gene enrichment allows the inclusion of other genes that in the human interactome space may also play(More)
The aim of this study was to identify single nucleotide polymorphisms (SNPs) that could be associated with back fat thickness (BFT) in pigs. To achieve this goal, we evaluated the potential and limits of an experimental design that combined several methodologies. DNA samples from two groups of Italian Large White pigs with divergent estimating breeding(More)
In pigs, many production traits are known to vary among breeds or lines. These traits can be considered end phenotypes or external traits as they are the final results of complex biological interactions and processes whose fine biological mechanisms are still largely unknown. This study was designed to compare plasma and serum metabolomic profiles between(More)
Precision medicine aims to predict a patient's disease risk and best therapeutic options by using that individual's genetic sequencing data. The Critical Assessment of Genome Interpretation (CAGI) is a community experiment consisting of genotype-phenotype prediction challenges; participants build models, undergo assessment, and share key findings. For CAGI(More)
Nuclear DNA sequences of mitochondrial origin (numts) are derived by insertion of mitochondrial DNA (mtDNA), into the nuclear genome. In this study, we provide, for the first time, a genome picture of numts inserted in the pig nuclear genome. The Sus scrofa reference nuclear genome (Sscrofa10.2) was aligned with circularized and consensus mtDNA sequences(More)
Shot-gun next generation sequencing (NGS) on whole DNA extracted from specimens collected from mammals often produces reads that are not mapped (i.e. unmapped reads) on the host reference genome and that are usually discarded as by-products of the experiments. In this study, we mined Ion Torrent reads obtained by sequencing DNA isolated from archived blood(More)
Intermuscular fat content in protected designations of origin dry-cured hams is a very important meat quality trait that affects the acceptability of the product by the consumers. An excess in intermuscular fat (defined as the level of fat deposition between leg muscles) is a defect that depreciates the final product. In this study we carried out a(More)