Samuel Perez

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Aging is associated with impaired learning and memory accompanied by reductions in adult hippocampal neurogenesis and brain expression of neurotrophic factors among other processes. Epigallocatechin-3-gallate (EGCG, a green tea catechin), β-alanine (β-ala, the precursor of carnosine), and exercise have independently been shown to be neuroprotective and to(More)
Though exercise is critical for health, many lack the motivation to exercise, and it is unclear how motivation might be increased. To uncover the molecular underpinnings of increased motivation for exercise, we analyzed the transcriptome of the striatum in four mouse lines selectively bred for high voluntary wheel running and four non-selected control(More)
Nutrition and physical exercise can enhance cognitive function but the specific combinations of dietary bioactives that maximize pro-cognitive effects are not known nor are the contributing neurobiological mechanisms. Epigallocatechin-3-gallate (EGCG) is a flavonoid constituent of many plants with high levels found in green tea. EGCG has anti-inflammatory(More)
We compared the potencies of systemic administration of bombesin (BN) and its mammalian homologue gastrin-releasing peptide (GRP) to decrease sham feeding in rats. Bombesin (at doses of 8, 16 and 32 micrograms/kg, intraperitoneally) inhibited sham feeding by 37% (p < 0.001), 58% (p < 0.001) and 65% (p < 0.001), respectively, confirming previous results.(More)
A first level of a methodology for the selection and evaluation of solvent at an early stage is presented inside a programming tool for its systematic and friendly application. This first level is based on properties and characteristics of solvents for their selection. Different tools are integrated into the program to aid the evaluation of the group of(More)
We report that the anorectic potency of neuromedin B (NMB) and gastrin-releasing peptide (GRP) is potentiated using a prefeed paradigm. During the light phase, adult male Sprague-Dawley rats (groups of n = 6) were given 30-min (pre-feed) access to a liquid diet. Thirty min later rats were injected i.p. with GRP or NMB (0, 8, 16, 32 or 64 micrograms kg-1)(More)
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