Samuel N. Acerbo

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1. The hypothesis was tested that the renal xanthine oxidase system provides a source of oxygen free radicals in puromycin aminonucleoside and adriamycin experimental nephrosis by generating uric acid from hypoxanthine and xanthine. 2. The concentrations in renal tissue of the putative intermediary products of puromycin aminonucleoside metabolism,(More)
A deta i led e x p l a n a t i o n of t he pos i t ion of t he v inyl g roup can on ly be g iven w h e n kinet ic s tud ies now in progress h a v e been comple ted . The resu l t s of th i s s t u d y are, however , in h a r m o n y wi th a r ecen t s t a t e m e n t of WINSTEIN and TRAYLOR ~) t h a t t he ra tes of electrophil ic s u b s t i t u t i o n on(More)
A major browning compound derived from lysine and glucose was purified by high performance chromatography on a RP8 column after several extractions in methanol plus acetonitrile. This compound was separated by a main contaminant corresponding to unreacted lysine by extracting the aminoacid after its derivatization with ninhydrin.
The renal selectivity properties towards albumin were evaluated in ten diabetic patients with arterial hypertension before and after the pharmacological normalisation of blood pressure, and were compared to 12 subjects with essential hypertension. While all patients of the control group were normoalbuminuric during hypertension, six of the diabetic group(More)
Ultrathin isoelectric focusing was employed for analyzing xanthine oxidase and enzymes with NADH-dependent dehydrogenase activity in homogenates of rat kidney. After isoelectric focusing the enzymes were stained with specific assays where NBT is reduced upon incubation of the gel with xanthine (oxidase stain) and NADH (dehydrogenase stain) as substrates. A(More)
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