Samuel Malone

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The combined effects of negative intrathoracic pressure swings during obstructive sleep apnoeas (OSAs) and increased sympathetic nervous system tone associated with hypoxia and sleep arousal may lead to pulmonary oedema or left-ventricular hypertrophy. Therefore, we have done a study of patients with congestive heart failure secondary to idiopathic dilated(More)
Enterohepatic recirculation of irinotecan and one of its metabolites, SN-38, has been observed in pharmacokinetic data sets from previous studies. A mathematical model that can incorporate this phenomenon was developed to describe the pharmacokinetics of irinotecan and its metabolites. A total of 32 patients with recurrent malignant glioma were treated with(More)
Summary) Although speculative activity is central to black markets for currency, the out-ofsample performance of structural models in those settings is unknown. We substantially update the literature on empirical determinants of black market rates and evaluate the outof-sample performance of linear models and nonparametric Bayesian treed Gaussian process(More)
In this paper, we introduce a class of quite general Lévy processes, with both a diffusion part and a pure jump component, as a prior distribution for log prices and volatilities in stochastic volatility models. This extends the work of Duffie et al. [2000] who model the jump part of the process as a compound Poisson process. Besides using a general Lévy(More)
In this paper, we describe a general method for constructing the posterior distribution of an option price. Our framework takes as inputs the prior distributions of the parameters of the stochastic process followed by the underlying, as well as the likelihood function implied by the observed price history for the underlying. Our work extends that of Karolyi(More)
In this paper, we describe a general method for constructing the posterior distribution of an option price. Our framework takes as inputs the prior distributions of the parameters of the stochastic process followed by the underlying, as well as the likelihood function implied by the observed price history for the underlying. Our work extends that of Karolyi(More)
— Studies that test the effect of economic outcomes on political transitions using weather variations as instruments have generally overlooked findings from climate science that economic output is a hill-shaped, rather than linear, function of temperature and precipitation levels. We design an improved set of instruments for growth based on this fact, and(More)