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BACKGROUND Enterohepatic recirculation of irinotecan and one of its metabolites, SN-38, has been observed in pharmacokinetic data sets from previous studies. A mathematical model that can incorporate this phenomenon was developed to describe the pharmacokinetics of irinotecan and its metabolites. PATIENTS AND METHODS A total of 32 patients with recurrent(More)
OBJECTIVE The objective of the present study was to evaluate the incidence, time of onset, and extent of hemoglobin, testosterone, and erythropoietin changes in patients with localized prostate cancer receiving either radiation alone or radiation combined with total androgen blockade (tab). METHODS The study enrolled 35 patients (median age: 69 years)(More)
We compared several procedures designed to modify consumer food purchases with the objectives of reducing fat and increasing carbohydrate content, and reducing dollar expenditures on food. Participants were 126 volunteer community households which, after a 7-week baseline period, were randomly assigned to video-modeling, video-modeling-feedback,(More)
— Studies that test the effect of economic outcomes on political transitions using weather variations as instruments have generally overlooked findings from climate science that economic output is a hill-shaped, rather than linear, function of temperature and precipitation levels. We design an improved set of instruments for growth based on this fact, and(More)
(Summary) Although speculative activity is central to black markets for currency, the out-of-sample performance of structural models in those settings is unknown. We substantially update the literature on empirical determinants of black market rates and evaluate the out-of-sample performance of linear models and nonparametric Bayesian treed Gaussian process(More)
In this paper, we describe a general method for constructing the posterior distribution of an option price. Our framework takes as inputs the prior distributions of the parameters of the stochastic process followed by the underlying, as well as the likelihood function implied by the observed price history for the underlying. Our work extends that of Karolyi(More)
Fifty-four patients with recurrent endometrial carcinoma were identified from a retrospective review of charts of 304 endometrial cancer patients seen between 1983 and 1989 at our center. A review was undertaken to identify the patterns of relapse, to determine the outcome of salvage treatment, to examine the factors predictive of effective salvage, and, if(More)
Fewer than 2% of patients with metastatic prostate cancer (pca) develop brain metastases. Autopsy series have confirmed the rarity of brain metastases. When present, brain metastases occur in end stage, once the pca is castrate-resistant and spread to other sites is extensive. Here, we present a rare case of a patient with pca who developed a solitary(More)