Samuel M. Brown

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UNLABELLED BACKGROUND Patients with severe sepsis or septic shock often exhibit significant cardiovascular dysfunction. We sought to determine whether severity of diastolic dysfunction assessed by transthoracic echocardiography (TTE) predicts 28-day mortality. METHODS In this prospective, observational study conducted in two intensive care units at a(More)
INTRODUCTION Prolonged ventilation and failed extubation are associated with increased harm and cost. The added value of heart and respiratory rate variability (HRV and RRV) during spontaneous breathing trials (SBTs) to predict extubation failure remains unknown. METHODS We enrolled 721 patients in a multicenter (12 sites), prospective, observational(More)
Clusters of nosocomial infection often occur undetected, at substantial cost to the medical system and individual patients. We evaluated binary cumulative sum (CUSUM) and moving average (MA) control charts for automated detection of nosocomial clusters. We selected two outbreaks with genotyped strains and used resistance as inputs to the control charts. We(More)
Whether ventilator-associated pneumonia is a manifestation of severity of illness or an independent cause of mortality in ventilator-dependent patients is not known. In this complex area, which cannot be readily subjected to randomized controlled trials, studies should focus on the underlying questions of relevance, how to improve care of ventilated(More)
BACKGROUND Sepsis is an often-fatal syndrome resulting from severe infection. Rapid identification and treatment are critical for septic patients. We therefore developed a probabilistic model to identify septic patients in the emergency department (ED). We aimed to produce a model that identifies 80 % of sepsis patients, with no more than 15 false positive(More)
Background. Spontaneous breathing trials (SBTs) are standard of care in assessing extubation readiness; however, there are no universally accepted guidelines regarding their precise performance and reporting. Objective. To investigate variability in SBT practice across centres. Methods. Data from 680 patients undergoing 931 SBTs from eight North American(More)
BACKGROUND Left ventricular diastolic dysfunction is common in patients with severe sepsis or septic shock, but the best approach to categorization is unknown. We assessed the association of common measures of diastolic function with clinical outcomes and tested the utility of a simplified definition of diastolic dysfunction against the American Society of(More)
BACKGROUND Patients' perceptions of the quality of their hospitalization have become important to the American healthcare system. Standard surveys of perceived quality of healthcare do not focus on the Intensive Care Unit (ICU) portion of the stay. Our objective was to evaluate the construct validity and internal consistency of the Intermountain Patient(More)
Erratum While compiling this article [1] one of the authors was inadvertently omitted from the author list. This author, The Canadian Critical Care Trials Group (CCCTG), has been included in the corrected author list above. Competing interests Andrew Seely is Founder and Chief Science Officer of Therapeutic Monitoring Systems (TMS); TMS aims to(More)
Binary cumulative sum charts, based on the theory of sequential probability ratio tests, monitor a cumulative term that is incremented or decremented by certain amounts for each positive or negative result, respectively, in order to sequentially test between user-specified acceptable and unacceptable rates (35,36) (Equation 1). In our application, the CUSUM(More)
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