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The Salvador-Warts-Hippo (SWH) pathway is an evolutionarily conserved regulator of tissue growth that is deregulated in human cancer. Upstream SWH pathway components convey signals from neighboring cells via a core kinase cassette to the transcription coactivator Yorkie (Yki). Yki controls tissue growth by modulating activity of transcription factors(More)
Anti-cancer drug development involves enormous expenditure and risk. For rapid and economical identification of novel, bioavailable anti-tumour chemicals, the use of appropriate in vivo tumour models suitable for large-scale screening is key. Using a Drosophila Ras-driven tumour model, we demonstrate that tumour overgrowth can be curtailed by feeding larvae(More)
The identification of bioavailable, tumour-specific anti-cancer compounds for clinical use by the conventional pharmaceutical pipeline of in vitro screening has been highly inefficient. The most direct manner of identifying such compounds would be to use in vivo screening using whole-animal tumour models. For such screens to be effective, very large(More)
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