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The root canal anatomy of 149 mandibular second molars was studied using a technique in which the pulp was removed, the canal space filled with black ink and the roots demineralized and made transparent. Of the 149 teeth, 22 per cent had single roots, 76 per cent had two roots and 2 per cent had three roots. In the single-rooted teeth, three canals were… (More)
The root canal anatomy of 19 mandibular second molars with C-shaped canals was investigated by rendering the roots transparent and allowing the canal system to be observed by black ink infiltration. The presence of three root canals was most frequent, and lateral canals were found in all roots. Transverse anastomoses were found in 15 of the 19 roots. The… (More)
The Salvador-Warts-Hippo (SWH) pathway is an evolutionarily conserved regulator of tissue growth that is deregulated in human cancer. Upstream SWH pathway components convey signals from neighboring cells via a core kinase cassette to the transcription coactivator Yorkie (Yki). Yki controls tissue growth by modulating activity of transcription factors… (More)
Currently there is no large animal model of dilated cardiomyopathy. The smaller animal models of cardiomyopathy, such as the Syrian hamster, cannot be studied with echocardiography and cardiac catheterization, and the relevance of these models to human dilated cardiomyopathy is open to question. On the basis of some initial observations in Doberman… (More)
Anti-cancer drug development involves enormous expenditure and risk. For rapid and economical identification of novel, bioavailable anti-tumour chemicals, the use of appropriate in vivo tumour models suitable for large-scale screening is key. Using a Drosophila Ras-driven tumour model, we demonstrate that tumour overgrowth can be curtailed by feeding larvae… (More)
Libraries of transgenic Drosophila melanogaster carrying RNA interference (RNAi) constructs have been used extensively to perform large-scale functional genetic screens in vivo. For example, RNAi screens have facilitated the discovery of multiple components of the Hippo pathway, an evolutionarily conserved growth-regulatory network. Here we investigate an… (More)
The tenets of root-canal treatment are the preparation, cleaning, and sealing of the root canals. An understanding of the variations in root-canal anatomy is necessary by those carrying out treatment. Recognition of a variation when it occurs is the first and most frequent step in completing successful treatment for these teeth.
Tests of the catharsis hypothesis involving viewed violence have led to conflicting results. It was suggested that the inconsistencies were due in part to the use of two different types of response measures, aggressive responses and hostile responses. This study involved a direct comparison of the two types of responses under conditions of instigation… (More)
The identification of bioavailable, tumour-specific anti-cancer compounds for clinical use by the conventional pharmaceutical pipeline of in vitro screening has been highly inefficient. The most direct manner of identifying such compounds would be to use in vivo screening using whole-animal tumour models. For such screens to be effective, very large… (More)
Warts is the central effector kinase of the Hippo growth-control pathway. In this issue of Developmental Cell, by assessing Warts conformation in vivo, Vrabioiu and Struhl (2015) report that the Mob family protein Mats regulates Warts activity allosterically, independent of phosphorylation by Hippo.