Samiran Saha

Learn More
The appearance of phosphatidylserine (PS) on the outer surface of red cells is an important signal for their uptake by macrophages. We report for the first time that procaspase 3 present in the anucleated mature human erythrocyte is activated under oxidative stress induced by t-butylhydroperoxide leading to impairment of the aminophospholipid translocase,(More)
Visceral leishmaniasis (VL) or kala-azar is known to be associated with a mixed Th1-Th2 response, and effective host defense requires the induction of IFN-gamma and IL-12. We address the role of the differential decline of IL-10 and TGF-beta in response to sodium antimony gluconate (SAG) and amphotericin B (AmB), the therapeutic success of SAG and AmB in(More)
Human infection with Leishmania results in diverse clinical and immunopathological situations. The capacity of the parasites to cause this wide range of disease manifestations depends upon their ability to evade the immune defense mechanisms by performing a well-tuned orchestra of hostparasite interactions inside the macrophages. While updated knowledge(More)
Diagnosis of post-kala-azar dermal leishmaniasis (PKDL), caused by Leishmania donovani, is difficult, as the dermal lesions are of several types and resemble those caused by other skin diseases, especially leprosy. Since the disease generally appears very late after the clinical cure of kala-azar in India, it is also difficult to correlate PKDL with a(More)
1. Chai JY, Murrell KD, Lymbery AJ. Fishborne parasitic zoonoses: status and issues. Int J Parasitol. 2005;35:1233–54. doi:10.1016/j.ijpara.2005.07.013 2. Andrews RH, Sithithaworn P, Petney TN. Opisthorchis viverrini: an underestimated parasite in world health. Trends Parasitol. 2008;24:497–501. doi:10.1016/j. pt.2008.08.011 3. Parish RA. Intestinal(More)
10.1128/JCM.43.3.1269-1277.2005. 2005, 43(3):1269. DOI: J. Clin. Microbiol. Dwijadas Banerjee and Nahid Ali Goswami, Netai Pramanik, Subhashis K. Guha, Sourjya Kar, Ravindran, Bibhas Bairagi, Bibhuti Saha, Ramapada Samiran Saha, Tuhina Mazumdar, Khairul Anam, Rajesh Post-Kala-Azar Dermal Leishmaniasis for Differential Diagnosis of Indian Immunosorbent Assay(More)
A novel series of quinolinone-based adenosine A(2B) receptor antagonists was identified via high throughput screening of an encoded combinatorial compound collection. Synthesis and assay of a series of analogs highlighted essential structural features of the initial hit. Optimization resulted in an A(2B) antagonist (2i) which exhibited potent activity in a(More)
  • 1