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- Publications
- Influence
Plasmodium subtilisin-like protease 1 (SUB1): Insights into the active-site structure, specificity and function of a pan-malaria drug target
- C. Withers-Martinez, C. Suarez, +8 authors M. Blackman
- Chemistry, Biology
- International journal for parasitology
- 15 May 2012
Release of the malaria merozoite from its host erythrocyte (egress) and invasion of a fresh cell are crucial steps in the life cycle of the malaria pathogen. Subtilisin-like protease 1 (SUB1) is a… Expand
Quinoxaline-Based Inhibitors of Malarial Protease PfSUB1*
- S. Kher, Maria Penzo, +4 authors A. Jirgensons
- Chemistry
- Chemistry of Heterocyclic Compounds
- 2014
2,3-Bis(phenylamino)quinoxalines have been identified as a novel class of malarial protease PfSUB1 inhibitors by screening of Malaria Box compounds. The synthesis of analog series and investigation… Expand
Substrate derived peptidic α-ketoamides as inhibitors of the malarial protease PfSUB1.
- S. Kher, Maria Penzo, Simone Fulle, P. Finn, M. Blackman, A. Jirgensons
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 15 September 2014
Peptidic α-ketoamides have been developed as inhibitors of the malarial protease PfSUB1. The design of inhibitors was based on the best known endogenous PfSUB1 substrate sequence, leading to… Expand