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Plasmodium subtilisin-like protease 1 (SUB1): Insights into the active-site structure, specificity and function of a pan-malaria drug target
- C. Withers-Martinez, C. Suarez, +8 authors M. Blackman
- Chemistry, Biology
- International journal for parasitology
- 15 May 2012
Release of the malaria merozoite from its host erythrocyte (egress) and invasion of a fresh cell are crucial steps in the life cycle of the malaria pathogen. Subtilisin-like protease 1 (SUB1) is a… Expand
Quinoxaline-Based Inhibitors of Malarial Protease PfSUB1*
2,3-Bis(phenylamino)quinoxalines have been identified as a novel class of malarial protease PfSUB1 inhibitors by screening of Malaria Box compounds. The synthesis of analog series and investigation… Expand
Substrate derived peptidic α-ketoamides as inhibitors of the malarial protease PfSUB1.
- S. Kher, Maria Penzo, Simone Fulle, P. Finn, M. Blackman, A. Jirgensons
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 15 September 2014
Peptidic α-ketoamides have been developed as inhibitors of the malarial protease PfSUB1. The design of inhibitors was based on the best known endogenous PfSUB1 substrate sequence, leading to… Expand
Design and Synthesis of Peptidic Alfa-Ketoamide-Based PfSUB1 Inhibitors