Samir Chhetri

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Ribonucleotide reductase (RR) is the enzyme that catalyses the rate-limiting step in DNA synthesis, the production of deoxynucleotides. RR activity is markedly elevated in tumour tissue and is crucial for cell division. It is therefore an excellent target for cancer chemotherapy. This study examined the anti-myeloma activity of Didox(More)
Cyclin D dysregulation and overexpression is noted in the majority of multiple myeloma (MM) patients, suggesting its critical role in MM pathogenesis. Here, we sought to identify the effects of targeting cyclin D in MM. We first confirmed cyclin D mRNA overexpression in 42 of 64 (65%) patient plasma cells. Silencing cyclin D1 resulted in >50% apoptotic cell(More)
Cardiovascular diseases (CVD) are the major contributor to the global burden of disease. Coronary heart disease, cerebrovascular disease, hypertension, artery disease, rheumatic heart disease, congenital heart disease and failure of heart came under the category of CVD. Epidemiological studies have suggested a link between atherosclerosis, infection and(More)
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