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New thiazolyl-coumarin hybrids: Design, synthesis, characterization, X-ray crystal structure, antibacterial and antiviral evaluation
Abstract A series of thiazole containing coumarin derivatives ( 2a-o ) were efficiently synthesized as pharmacophore hybrids through Hantzsch cyclisation of 3-(2-bromoacetyl)-2 H -chrome-2-ones withExpand
4-Thiazolidinone coumarin derivatives as two-component NS2B/NS3 DENV flavivirus serine protease inhibitors: synthesis, molecular docking, biological evaluation and structure–activity relationship
TLDR
4-thiazolidinone coumarin derivatives are discovered as a new scaffold that may eventually yield useful compounds in the treatment of bacterial and viral infections. Expand
Molecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/B and β-amyloid inhibitors for Alzheimer’s disease
TLDR
The objective of this review is to focus on the construction of these pharmacologically important coumarin analogues with anti-Alzheimer’s activities, highlight their docking studies and structure–activity relationships based on their substitution pattern with respect to the selected positions on the chromen ring by emphasising on the research reports conducted in between year 1968 to 2017. Expand
GC-MS analysis of chemical constituents and in vitro antioxidant activity of the organic extracts from the stem of Bridelia stipularis
In the present study the stems of the Bridelia stipularis (L.) Blume, which is traditionally used by ethnic communities in Sabah, Malaysia, has been investigated for its chemical composition, totalExpand
Synthesis , Characterisation and Cytotoxicity Activity of Thiazole Substitution of Coumarin Derivatives ( Characterisation of Coumarin Derivatives )
Three types of coumarin derivatives were synthetised using the Knoevenagel condensation technique. All of these compounds have been characterised by the Fourier Transform Infrared (FTIR) and theExpand
3-(2-Methylamino-1,3-thiazol-4-yl)-2H-chromen-2-one
TLDR
In the title compound, C13H10N2O2S, the essentially planar 2H-chromene ring system and the thiazole ring form a dihedral angle of 3.47 (5)°. Expand
Synthesis, X-ray crystallographic study, pharmacology and docking of hydrazinyl thiazolyl coumarins as dengue virus NS2B/NS3 serine protease inhibitors
A series of total twenty-one thiazole-coumarin derivatives 7a-u, linked via hydrazine linkage were synthesized through Hantzsch cyclisation. Out of twenty-one derivatives, fourteen derivatives viz.Expand
Chemical composition and antioxidant activity of essential oil of leaves and flowers of Alternanthera sessilis red from Sabah
TLDR
The chemical composition and antioxidant activity of essential oil from the aerial parts of Alternanthera sessilis red has been investigated and the major components of essentialOil of leaves, as analyzed by the GC-MS were found to be 1,1,1-5,5, 5,5-hexamethyl-3,3-bis[trimethylsilyl)oxy]trisiloxane. Expand
3β-Acetoxy-5α-cholestan-6-one 2-cyanoacetylhydrazone
The asymmetric unit of the title compound, C32H51N3O3, consists of two crystallographically independent molecules, A and B; the 2-methylpentane group of molecule A and the propane group of molecule BExpand
3β-Chloro-6-[2-(2-cyanoacetyl)hydrazin-1-ylidene]-5α-cholestane
The asymmetric unit of the title compound, C30H48ClN3O, contains two molecules, A and B. In both molecules, the three cyclohexane rings in the steroid fused ring systems adopt chair conformations,Expand
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