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Methylation of the N(6) position of adenosine (m(6)A) is a posttranscriptional modification of RNA with poorly understood prevalence and physiological relevance. The recent discovery that FTO, an… (More)
- Samie R. Jaffrey, Hediye Erdjument-Bromage, Christopher Ferris, Paul Tempst, Solomon H Snyder
- Nature Cell Biology
- 2001
Nitric oxide (NO) has been linked to numerous physiological and pathophysiological events that are not readily explained by the well established effects of NO on soluble guanylyl cyclase. Exogenous… (More)
- Samie R. Jaffrey, Solomon H Snyder
- Science's STKE : signal transduction knowledge…
- 2001
Many of the effects of nitric oxide are mediated by the direct modification of cysteine residues resulting in an adduct called a nitrosothiol. Here, we describe a novel method for detecting proteins… (More)
Nitric oxide (NO) produced by neuronal nitric oxide synthase (nNOS) is important for N-methyl-D-aspartate (NMDA) receptor-dependent neurotransmitter release, neurotoxicity, and cyclic GMP elevations.… (More)
- Karen Y. Wu, Ulrich Hengst, +4 authors Samie R. Jaffrey
- Nature
- 2005
Neuronal development requires highly coordinated regulation of the cytoskeleton within the developing axon. This dynamic regulation manifests itself in axonal branching, turning and pathfinding,… (More)
- Jeremy S Paige, Karen Y. Wu, Samie R. Jaffrey
- Science
- 2011
Green fluorescent protein (GFP) and its derivatives have transformed the use and analysis of proteins for diverse applications. Like proteins, RNA has complex roles in cellular function and is… (More)
- Ming Fang, Samie R. Jaffrey, Akira Sawa, Keqiang Ye, Xiaojiang Luo, Solomon H Snyder
- Neuron
- 2000
Because nitric oxide (NO) is a highly reactive signaling molecule, chemical inactivation by reaction with oxygen, superoxide, and glutathione competes with specific interactions with target proteins.… (More)
- Samie R. Jaffrey, Solomon H Snyder
- Science
- 1996
The neurotransmitter functions of nitric oxide are dependent on dynamic regulation of its biosynthetic enzyme, neuronal nitric oxide synthase (nNOS). By means of a yeast two-hybrid screen, a… (More)
- Deepak P. Patil, Chun-Kan Chen, +4 authors Samie R. Jaffrey
- Nature
- 2016
The long non-coding RNA X-inactive specific transcript (XIST) mediates the transcriptional silencing of genes on the X chromosome. Here we show that, in human cells, XIST is highly methylated with at… (More)
- Bastian Linder, Anya V. Grozhik, Anthony O. Olarerin-George, Cem Meydan, Christopher E. Mason, Samie R. Jaffrey
- Nature Methods
- 2015
N6-methyladenosine (m6A) is the most abundant modified base in eukaryotic mRNA and has been linked to diverse effects on mRNA fate. Current mapping approaches localize m6A residues to transcript… (More)