Samia H Shalaby

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Physical mixtures of ketoprofen (KT) were prepared using different excipients, namely, lactose, mannitol, sorbitol, beta-cyclodextrin, polyvinylpyrolidone (PVP) K30, polyethyleneglycol (PEG) 20,000 and urea in a ratio of 2:1 (drug/excipient). The prepared samples as well as KT alone were stored at 40, 50 and 60 degrees C in sealed glass vials for 12 weeks.(More)
In this work lyophilized poly-ε-caprolactone nanoparticles (NPs) loaded with atorvastatin calcium (AC) were developed in an attempt to improve the in-vivo performance of AC following oral administration. The individual and combined effects of several formulation variables were previously investigated using step-wise full factorial designs in order to(More)
The aims of our investigation were to develop and optimize ciclopirox (CPX) nail lacquer using nonbiodegradable Eudragit RLPO (E-RLPO) as a film former and to assess its penetration efficiency across the human nail plate. Preliminary trials such as hydration enhancement factor (HEF), a retained drug in the nail plate, and SEM were studied to select the(More)
Quantitative and comparative investigation of the electronic absorption spectra of theophylline, caffeine and their derivatives is reported. The spectra of theophylline, caffeine and theobromine were compared to establish the predominant tautomeric species in solution. This comparison, analysis of solvent effects and assignments of the observed transitions(More)
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