Sameer Sapra

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The purpose of the study was to develop tumor specific, water dispersible superparamagnetic iron oxide nanoparticles (SPIONs) and evaluate their efficacy as a contrast agent in magnetic resonance imaging (MRI). We have developed SPIONs capped with citric acid/2-bromo-2-methylpropionic acid which are compact, water dispersible, biocompatible having narrow(More)
Semiconductor quantum dots and superparamagnetic iron oxide nanocrystals have physical properties that are well suited for biomedical imaging. Previously, we have shown that iron oxide nanocrystals embedded within the lipid core of micelles show optimized characteristics for quantitative imaging. Here, we embed quantum dots and superparamagnetic iron oxide(More)
Xanthine oxidase is a complex molybdoflavoprotein that catalyses the hydroxylation of xanthine to uric acid. Fifty three analogues of 1-acetyl-3,5-diaryl-4,5-dihydro(1H)pyrazoles were rationally designed and synthesized and evaluated for in vitro xanthine oxidase inhibitory activity for the first time. Some notions about structure activity relationships are(More)
CdSeS nanocrystals with different bandgap energies have been synthesized by the colloidal method. The solution blend of blue-, green- and red-emitting CdSeS nanocrystals, in appropriate proportions, showed strong white emission of different shades on excitation with a UV source. We observed that the CIE coordinate of the spectrum of a particular blend is(More)
We report results of the studies relating to electrophoretic deposition of nanostructured composite of chitosan (CS)-cadmium-telluride quantum dots (CdTe-QDs) onto indium-tin-oxide coated glass substrate. The high resolution transmission electron microscopic studies of the nanocomposite reveal molecular level coating of the CdTe-QDs with CS molecules in the(More)
We present white light generation controlled and tuned by multi-color quantum-dot-quantum-well emitters made of onion-like CdSe/ZnS/CdSe core/shell/shell heteronanocrystals integrated on InGaN/GaN light-emitting diodes (LEDs). We demonstrate hybrid white LEDs with (x, y) tristimulus coordinates tuned from (0.26, 0.33) to (0.37, 0.36) and correlated color(More)
We report the synthesis and characterization of several sizes of Mn-doped ZnO nanocrystals, both in the free-standing and the capped particle forms. The sizes of these nanocrystals could be controlled by capping them with polyvinylpyrollidone under different synthesis conditions and were estimated by X-ray diffraction and transmission electron microscopy.(More)
A series of forty two N-(1,3-diaryl-3-oxopropyl)amides were synthesized via an efficient, modified Dakin-West reaction and were evaluated for in vitro xanthine oxidase inhibitory activity for the first time. Structure-activity relationship analyses have been presented. Selected active xanthine oxidase inhibitors (3r, 3s, and 3zh) were assessed in vivo to(More)
Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are collectively known as chalcones. These show antibacterial, antifungal, antitumour and anti-inflammatory properties, and also are intermediates in the biosynthesis of flavonoids, substances widespread in plants with an array of biological(More)
This study is based on the synthesis of a series of combretastatin analogs with different substitutions on one aryl moiety and a carboxylic group in connecting chain. Cis-configuration with respect to aryl groups was established by X-ray crystal analysis. All the synthesized compounds were evaluated for anticancer activity against a panel of cell lines. Six(More)