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The Biology of Vasopressin
Growing knowledge of the central biological roles of vasopressin has enabled pharmacological advances to treat these conditions by targeting defective systemic or central pathways utilizing specific agonists and antagonists.
Hof1 plays a checkpoint-related role in MMS-induced DNA damage response in Candida albicans
This work expands the understanding of the C. albicans DNA repair network and uncovers interplay between the cytokinesis regulator Hof1 and the Rad53-mediated checkpoint.
Polysorbate 80-Induced Anaphylactoid Reaction and the Effects on Cardiovascular Function: Dose Threshold and Species Comparison
It is suggested that mild, transient skin changes occur following PS80 administration at doses that are not associated with CV effects in the dogs, and monkeys and minipigs did not induce CV, cutaneous or histamine concentration changes.
Characterization of a novel separase-interacting protein and candidate new securin, Eip1p, in the fungal pathogen Candida albicans
The results introduce a candidate new securin, provide an approach for identifying these divergent proteins, reveal a putative anti-fungal therapeutic target, and highlight variations in mitotic regulation in eukaryotes.
Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome
It is demonstrated that both wild-type and cell cycle-defective mutants of Vpr induce the degradation of APC1, an essential APC/C scaffolding protein, and show that this activity relies on the recruitment of DCAF1 by Vpr and the presence of a functional proteasome.
Characterization of a putative separase Esp1p and a novel interacting protein in regulating mitosis in the fungal pathogen Candida albicans
The C. albicans separase homologue, ESP1, is demonstrated to be required for chromosome segregation, and new insights on factors involved in the metaphase-to-anaphase transition, and thus cell proliferation in C.Albicans are provided.