Samantha Michelle Walker

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BACKGROUND Grass pollen immunotherapy for allergic rhinitis is a disease-modifying treatment that results in long-term clinical tolerance lasting years after treatment discontinuation. Active treatment is associated with generation of inhibitory grass pollen-specific IgG antibodies capable of blocking allergen-IgE interactions. OBJECTIVES We sought to(More)
Mycoplasma genitalium is a cause of non-gonoccocal urethritis (NGU) in men and cervicitis and pelvic inflammatory disease in women. Recent international data also indicated that the first line treatment, 1 gram stat azithromycin therapy, for M. genitalium is becoming less effective, with the corresponding emergence of macrolide resistant strains. Increasing(More)
BACKGROUND Whilst qPCR provides an extremely powerful tool for genetic analysis, some applications such as multiplexing variant alleles (eg SNPs, point mutations or deletions), remain challenging using current primer/probe systems. The novel design features of PlexPrimers allow sensitive, multiplexed analysis of variant alleles even when these are tightly(More)
A BSTRACT Background: Grass pollen immunotherapy is highly effective in reducing seasonal hay fever symptoms and medication requirements. Clinical improvement is accompanied by a reduction in nasal mucosal eosi-nophils, although the mechanism is unknown. Methods: Nasal biopsies were taken from 37 adults before immunotherapy and during the peak pollen season(More)
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