Samantha M Wileman

Learn More
OBJECTIVE To determine the relative benefits and risks of laparoscopic fundoplication surgery as an alternative to long term drug treatment for chronic gastro-oesophageal reflux disease (GORD). DESIGN Multicentre, pragmatic randomised trial (with parallel preference groups). SETTING 21 hospitals in the United Kingdom. PARTICIPANTS 357 randomised(More)
BACKGROUND Little is known about the presentation and management of seasonal affective disorder (SAD) in primary care. AIMS To determine the use of health care services by people suffering from SAD. METHOD Following a screening of patients consulting in primary care, 123 were identified as suffering from SAD. Each was age- and gender-matched with two(More)
A number of factors can result in the temporary suspension of randomisation in clinical trials, with the most common being safety, effectiveness and recruitment. However, external factors such as commercial, political, patient and media pressure can also have a significant impact on decisions to temporarily suspend randomisation. When the decision has been(More)
Trial start up is a frenetic time for any trial manager: once a trial has been funded the clock is ticking to get the first participant recruited. There are a number of key activities that need to happen during this stage, so developing standardised processes to help improve effectiveness can make the system more efficient, and help promote best practice.(More)
OBJECTIVES Within a trial of medical and surgical treatments for gastro-esophageal reflux disease (GORD), involving randomised arms and preference arms, we tested the applicability of the Beliefs about Medicines Questionnaire (BMQ) and developed and tested the validity of a new Beliefs about Surgery Questionnaire (BSQ). METHODS Patients with GORD (N = 43)(More)
  • 1