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- Samantha L. Hoopes, VÃctor Garcia, Matthew L Edin, Michal Laniado Schwartzman, Darryl C. Zeldin
- Prostaglandins & other lipid mediators
- 2015
20-hydroxyeicosatetraenoic acid (20-HETE) is a metabolite of arachidonic acid that exhibits a myriad of biological effects in the vascular system. This review discusses the current knowledge related… (More)
- Klara R. Klein, Natalie O. Karpinich, +6 authors Kathleen M I Caron
- Developmental cell
- 2014
Atypical 7-transmembrane receptors, often called decoy receptors, act promiscuously as molecular sinks to regulate ligand bioavailability and consequently temper the signaling of canonical G… (More)
- Samantha L. Hoopes, Helen H. Willcockson, Kathleen M I Caron
- PloS one
- 2012
Adrenomedullin (AM) and its receptor complexes, calcitonin receptor-like receptor (Calcrl) and receptor activity modifying protein 2/3, are highly expressed in lymphatic endothelial cells and are… (More)
- Natalie O. Karpinich, Samantha L. Hoopes, Daniel O Kechele, Patricia M. Lenhart, Kathleen M I Caron
- Current hypertension reviews
- 2011
Adrenomedullin is a highly conserved peptide implicated in a variety of physiological processes ranging from pregnancy and embryonic development to tumor progression. This review highlights past and… (More)
- Samantha L. Hoopes, Artiom Gruzdev, +6 authors Darryl C. Zeldin
- PloS one
- 2017
Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs), which play an important role in blood pressure regulation, protection against… (More)
- Joan P. Graves, Artiom Gruzdev, +6 authors Darryl C. Zeldin
- Drug metabolism and disposition: the biological…
- 2015
Members of the cytochrome P450 CYP2J subfamily are expressed in multiple tissues in mice and humans. These enzymes are active in the metabolism of fatty acids to generate bioactive compounds. Herein… (More)
- Matthew L Edin, Behin Gholipour Hamedani, +10 authors Darryl C. Zeldin
- The Journal of biological chemistry
- 2018
Stimuli such as inflammation or hypoxia induce cytochrome P450 epoxygenase-mediated production of arachidonic acid-derived epoxyeicosatrienoic acids (EETs). EETs have cardioprotective, vasodilatory,… (More)
- Zuowen He, Xu Zhang, +4 authors Dao Wen Wang
- Cardiovascular research
- 2015
AIMS
Cardiac remodelling is one of the key pathological changes that occur with cardiovascular disease. Previous studies have demonstrated the beneficial effects of CYP2J2 expression on cardiac… (More)
- Xizhen Xu, Rui Li, Guangzhi Chen, Samantha L. Hoopes, Darryl C. Zeldin, Dao Wen Wang
- Advances in nutrition
- 2016
Metabolic diseases are associated with an increased risk of developing cardiovascular disease. The features comprising metabolic diseases include obesity, insulin resistance, hyperglycemia,… (More)
- Shasha Zhang, Guangzhi Chen, +8 authors Xizhen Xu
- Obesity
- 2015
OBJECTIVE
The study aims to investigate the effect of cytochrome P450 2J2 (CYP2J2) overexpression on hyperlipidemia in mice and further to explore its effect on fatty acid oxidation in vivo and in… (More)