Samantha L. Shipman

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Little is known of the environmental factors that initiate and promote disease. The aryl hydrocarbon receptor (AHR) is a key regulator of xenobiotic metabolism and plays a major role in gene/environment interactions. The AHR has also been demonstrated to carry out critical functions in development and disease. A qualitative investigation into the(More)
BACKGROUND Obesity is a growing worldwide problem with genetic and environmental causes, and it is an underlying basis for many diseases. Studies have shown that the toxicant-activated aryl hydrocarbon receptor (AHR) may disrupt fat metabolism and contribute to obesity. The AHR is a nuclear receptor/transcription factor that is best known for responding to(More)
RATIONALE The antiangiogenic activity of rPAI-1(23), a truncated plasminogen activator inhibitor-1 (PAI-1) protein, induces vasa vasorum collapse and significantly reduces plaque area and plaque cholesterol in hypercholesterolemic low-density lipoprotein receptor-deficient/apolipoprotein B48-deficient mice. OBJECTIVE The objective of this study was to(More)
V asa vasorum are a network of microvasculature that originate primarily in the adventitia of large arteries. They supply oxygen and nutrients to the outer layers of the arterial wall which are beyond the limit of diffusion from the luminal surface. 1 Vasa vasorum become angiogenic during atheroscle-rosis in humans 2,3 and in mouse models of(More)
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