Samantha L. Price

Learn More
Polyclonal antisera were generated against two identical regions of rat and human A1 adenosine receptors using synthetic multiple-antigenic-peptides as immunogens. Western blotting showed that the antisera recognized a single protein in brain of the expected size for A1 receptors. Immunohistochemistry of CHO cells transfected with the rat or human A1(More)
Alzheimer's disease (AD) is a neurodegenerative pathology with relevant unmet therapeutic needs. Both natural aging and AD have been associated with a significant decline in the omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA), and accordingly, administration of DHA has been proposed as a possible treatment for this pathology. However, recent(More)
Sepsis and its related syndromes represent potentially devastating illnesses, estimated to account for 1% of all hospital admissions and for 100 000 deaths per annum in the U.S.A. alone. Although sepsis is defined as the systemic response to infection, an infective organism is found in fewer than 50% of cases. It is therefore increasingly recognised that(More)
We investigate the suggestion that aromatic rings can act as hydrogen-bond acceptors in proteins, by an analysis of 55 non-homologous high-resolution protein chain structures. Approximately 10% of interactions between sp2 hybridized nitrogen atoms, from either side-chains or main-chains, and phenylalanine or tyrosine rings have the nitrogen atom positioned(More)
We have made a comparison of the geometries of intra- and intermolecular arginine-aspartate interactions by extracting orientation information from protein co-ordinate data. The results show a pronounced difference, with both types of interaction preferring to form twin N-H . . . O = C hydrogen bonds, but involving different nitrogen atoms. In(More)
The hormone PYY is released from the distal gut in response to nutrient ingestion. Numerous studies have shown that PYY3-36, the most abundant circulating isoform of PYY, reduces food intake when given to obese rodents and humans. Its infusion to mimic postprandial levels in fasting subjects inhibits appetite, suggesting a physiological role in postprandial(More)
AIMS To investigate the effect of Glu-3 OXM-like analogues on food intake and bodyweight in male rats. BACKGROUND Oxyntomodulin (OXM) is a natural agonist at both the glucagon receptor (GCGr) and the glucagon-like peptide 1 receptor (GLP-1r), and peripheral administration reduces food intake and increases energy expenditure in rodents and humans.(More)
Introduction Inadequate cardiac output is associated with poor outcome following cardiac surgery and is generally modified by use of inotropic agents, volume resuscitation and epicardial pacing. Although temporary epicardial pacing is frequently utilised post-cardiac surgery, the potential impact of determining the optimal R-R interval in the critically ill(More)