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The complete amino acid sequence of human neutrophil elastase has been determined. The protein consists of 218 amino acid residues, contains two asparagine-linked carbohydrate side chains, and is joined together by four disulfide bonds. Comparison of the sequence to other serine proteinases indicates only moderate homology with porcine pancreatic elastase(More)
One hundred Macaca mulatta, trapped in India and transported directly to the California Primate Research Center, were surveyed for the prevalence of gastrointestinal helminths. Trichostrongylus sp. was found in 86% of the animals, followed by Strongyloides fulleborni (63%), Streptopharagus sp. (38%), Oesophagostomum sp. (23%) and Anatrichosoma sp. (21%).(More)
Active learning is an important component of pharmacy education. By engaging students in the learning process, they are better able to apply the knowledge they gain. This paper describes evidence supporting the use of active-learning strategies in pharmacy education and also offers strategies for implementing active learning in pharmacy curricula in the(More)
The overall prognosis of primary amoebic meningoencephalitis remains poor. The results of this study support previous finding that amphotericin B is the most efficacious drug against the Naegleria species in in vitro testing. In addition, the methyl ester of amphotericin B, a new derivative, also appears to be an effective agent. Of the drug combinations(More)
A group of wild caught rhesus monkeys and their domestic born infants were examined for Anatrichosoma, a nematode that inhabits the nasal mucosa and subcutaneous tissue of the face, hands, and feet. The diagnosis was made using nasal swabs. Fifty-four percent of the wild caught animals reported positive ina survey taken 3 years earlier were negative based(More)
Studies were conducted on 27 Old World monkeys to determine their susceptibility to pathogenic strains (HB-1 and C-66) of Naegleria fowleri by intranasal, intravenous, or intrathecal inoculation of trophozoites. No clinically detectable disease resulted from either intranasal or intravenous inoculation, but 11 of 18 monkeys inoculated intrathecally(More)