Samantha Jane Alsbury

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Leucine-rich repeats (LRRs) are highly versatile and evolvable protein-ligand interaction motifs found in a large number of proteins with diverse functions, including innate immunity and nervous system development. Here we catalogue all of the extracellular LRR (eLRR) proteins in worms, flies, mice and humans. We use convergent evidence from several(More)
The forebrain cholinergic system consists of the cholinergic interneurons of the striatum and projection neurons that are distributed in loosely defined groups along the basal forebrain. Forebrain cholinergic neurons (FCNs) are born between E11 and E15, begin to express cholinergic markers at late embryonic stages, invade their projection target areas(More)
Correction to Dolan J, Walshe K, Alsbury S, Hokamp K, O'Keeffe S, Okafuji T, Miller SF, Tear G, Mitchell KJ: The extracellular leucine-rich repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns. BMC Genomics 2007, 8:320.
The outgrowth of many neurons within the central nervous system is initially directed towards or away from the cells lying at the midline. Recent genetic evidence suggests that a simple model of differential sensitivity to the conserved Netrin attractants and Slit repellents is insufficient to explain the guidance of all axons at the midline. In the(More)
Cardiotrophin-1 (CT-1) and Urocortin (UCN) are peptides which have previously been shown to have protective effects in cardiac myocytes and which induce heat shock protein expression. CT-1 is a member of the interleukin-6 family of cytokines. UCN is a peptide expressed in the brain that binds to the corticotrophin releasing hormone receptors. In this(More)
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