Samantha J. Leach

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This open-label multi-centre study evaluated a new intravenous immunoglobulin, Gammaplex®, in the treatment of 50 patients with primary immunodeficiency and significant hypogammglobulinaemia. Patients treated previously with other intravenous immunoglobulins received Gammaplex® on their same infusion schedule for 1 year; 22 were on a 21-day and 28 on a(More)
Recent advances in neuroimaging have enabled researchers to establish relatively specific areas of the brain that are involved in working memory. In this positron emission tomography study we examined the pattern of neural activation associated with performance on number-letter sequencing, a purported measure of working memory included in the new Wechsler(More)
Neuropsychological studies have documented frontal dysfunction in patients with a history of exposure to organic solvents. The deficits typically observed in these patients appear to be related to working memory (WM). This study used [15O] water positron emission tomography (PET) to examine the pattern of neural activation during verbal working memory in(More)
Lesion studies have demonstrated that frequency memory, or memory for the frequency of occurrence, is associated with prefrontal and not temporal lobe lesions. This study examined neural activation during performance on a frequency-memory-judgment task and a recognition-memory task, both using words. Relative to a control task, the authors observed peaks of(More)
cancer was carried out by this same observer and the results confirmed her previous observation. More recently Remy et al. (1983) carried out a similar study; from data given in their Figure 1, the relative risk of cancer is approximately 6 in individuals having an average of less than one cold per year over the 10 years before diagnosis compared to those(More)
Intragastric nitrosation has been implicated in the pathogenesis of gastric cancer and in precancerous conditions such as pernicious anaemia and the post-gastrectomy state. Intragastric nitrosation was assessed in at-risk patients by N-nitrosoproline (NPRO) excretion using both a conventional and a modified test. Twenty-four hour urinary excretion of NPRO(More)
A total of 521 patients consecutively admitted to an acute geriatric unit were kept under surveillance by one observer during their stay. All drugs given to them and the occurrence of adverse events were recorded. One hundred and seventeen adverse drug reactions occurred in 94 patients representing 18.8% of the 500 patients receiving drugs. Thirteen of(More)
BACKGROUND AND OBJECTIVES This multicentre, open-label study investigated the safety and efficacy of Gammaplex, a 5% Intravenous Immunoglobulin (IVIg), in patients with idiopathic (immune) thrombocytopenic purpura (ITP). MATERIALS AND METHODS Patients were between the ages of 6 and 70 years; had ITP for at least six months and had a platelet count ≤ 20 ×(More)