Samantha Creighton

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23. Budding yeast cells detect a single impaired chromosome , very likely because of improper spindle attachment [M. 30. The hazards caused by pairing and recombination are unique to the first meiotic division, and the response , an exposed kinetochore, is also unique to that division. In the second meiotic division, the ki-netochores are arranged just as(More)
Substantial evidence implicates Acetylcholine (ACh) in the acquisition of object memories. While most research has focused on the role of the cholinergic basal forebrain and its cortical targets, there are additional cholinergic networks that may contribute to object recognition. The striatum contains an independent cholinergic network comprised of(More)
The importance of histone acetylation for certain types of memory is now well established. However, the specific contributions of the various histone acetyltransferases to distinct memory functions remain to be determined; therefore, we employed selective histone acetyltransferase protein inhibitors and short-interference RNAs to evaluate the roles of(More)
Epigenetic mechanisms are increasingly acknowledged as major players in memory formation. Specifically, DNA methylation is necessary for the formation of long-term memory in various brain regions, including the hippocampus (HPC); however, its role in the perirhinal cortex (PRh), a structure critical for object memory, has not been characterized. Moreover,(More)
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