Samane Ghazanfari

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Bone marrow mesenchymal stem cells (MSCs) are capable of differentiating into a variety of cell types such as vascular smooth muscle cells (SMCs). In this study, we investigated influence of cyclic stretch on proliferation of hMSCs for different loading conditions, alignment of actin filaments, and consequent differentiation to SMCs. Isolated cells from(More)
Collagen is the main load-bearing component of the artery. The 3D arrangement of the collagen fibers is crucial to understand the mechanical behavior of such tissues. We compared collagen fiber alignment obtained by second harmonic generation (SHG) microscopy with the alignment obtained by diffusion tensor imaging (DTI) throughout the wall of a porcine(More)
UNLABELLED Collagen fiber anisotropy has a significant influence on the function and mechanical properties of cardiovascular tissues. We investigated if strain-dependent collagen degradation can explain collagen orientation in response to uniaxial and biaxial mechanical loads. First, decellularized pericardial samples were stretched to a fixed uniaxial(More)
Bone marrow mesenchymal stem cells (MSCs) are capable of self-renewal and can differentiate into multiple non-hematopoietic cell lineages such as smooth muscle cells (SMCs). Mechanical stimulations are critical to morphological changes, development, regeneration, and pathology of mesenchymal tissues. The type of mechanical stimulation applied on the cells(More)
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