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Hypotaurine evokes a malignant phenotype in glioma through aberrant hypoxic signaling

• Peng Gao, Chunzhang Yang, +13 authors Guowang Xu
• Oncotarget
• 2016

Metabolomics has shown significant potential in identifying small molecules specific to tumor phenotypes. In this study we analyzed resected tissue metabolites using capillary electrophoresis-mass… (More)

A dynamic in vivo-like organotypic blood-brain barrier model to probe metastatic brain tumors

• Hui Xu, Zhongyu Li, +9 authors Jianhua Qin
• Scientific reports
• 2016

The blood-brain barrier (BBB) restricts the uptake of many neuro-therapeutic molecules, presenting a formidable hurdle to drug development in brain diseases. We proposed a new and dynamic in… (More)

Loss of Quiescence in von Hippel-Lindau Hemangioblastomas is Associated with Erythropoietin Signaling

• Michael J. Feldman, Saman Sizdahkhani, +6 authors Prashant Chittiboina
• Scientific reports
• 2016

von Hippel-Lindau (VHL) patients develop multiple central nervous system hemangioblastomas (HB). Some HBs become symptomatic with exponential growth or cyst formation following long periods of… (More)

LB-100, a novel Protein Phosphatase 2A (PP2A) inhibitor, sensitizes malignant meningioma cells to the therapeutic effects of radiation.

• Winson S. Ho, Saman Sizdahkhani, +11 authors Deric M. Park
• Cancer letters
• 2018

Atypical and anaplastic meningiomas (AAM) represent 20% of all meningiomas. They are associated with poor outcomes due to their tendency to recur. While surgery and radiation (RT) are first line… (More)

367 Autocrine/Paracrine Erythropoietin Signaling Associated With Symptomatic von Hippel-Lindau Hemangioblastomas.

• Saman Sizdahkhani, X Wang, +4 authors Prashant Chittiboina
• 2016

Somatostatin receptor expression on von Hippel-Lindau-associated hemangioblastomas offers novel therapeutic target

• Saman Sizdahkhani, Michael J. Feldman, +8 authors Prashant Chittiboina
• Scientific reports
• 2017

Von Hippel-Lindau (VHL)-associated hemangioblastomas (VHL-HB) arise in the central nervous system (CNS), and are a leading cause of morbidity and mortality in VHL disease. Currently, surgical… (More)

Hypoxia in the glioblastoma microenvironment: shaping the phenotype of cancer stem-like cells.

• Nicole Makas Colwell, Mioara Larion, +4 authors Deric M. Park
• Neuro-oncology
• 2017

Glioblastoma is the most common and aggressive malignant primary brain tumor. Cellular heterogeneity is a characteristic feature of the disease and contributes to the difficulty in formulating… (More)

367 Autocrine/Paracrine Erythropoietin Signaling Associated With Symptomatic von Hippel-Lindau Hemangioblastomas.

• Saman Sizdahkhani, X Wang, +4 authors Prashant Chittiboina
• 2016

INTRODUCTION Von Hippel-Lindau (VHL) disease is an autosomal dominant neoplastic disorder leading to formation of multiple central nervous system hemangioblastomas (HBs). (1) Although most… (More)

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