Corrigendum: A diverse range of gene products are effectors of the type I interferon antiviral response
- J. Schoggins, Sam J. Wilson, C. Rice
- PsychologyNature
- 1 September 2015
This corrects the article to show that the Higgs boson genome is a “spatially aggregated “vessel” rather than an “ aggregating “ nucleus”, which is more closely related to DNA than to RNA.
A diverse array of gene products are effectors of the type I interferon antiviral response
- J. Schoggins, Sam J. Wilson, C. Rice
- BiologyNature
- 10 April 2011
It is shown that different viruses are targeted by unique sets of ISGs, and that each viral species is susceptible to multiple antiviral genes, which together encompass a range of inhibitory activities.
Nef proteins from simian immunodeficiency viruses are tetherin antagonists.
- Fengwen Zhang, Sam J. Wilson, T. Hatziioannou
- BiologyCell Host and Microbe
- 23 July 2009
MX2 is an interferon-induced inhibitor of HIV-1 infection
- M. Kane, S. Yadav, P. Bieniasz
- Biology, ChemistryNature
- 13 October 2013
Overall, these findings indicate that MX2 is an effector of the anti-HIV-1 activity of type-I IFN, and suggest thatMX2 inhibits HIV-1 infection by inhibiting capsid-dependent nuclear import of subviral complexes.
Independent evolution of an antiviral TRIMCyp in rhesus macaques
- Sam J. Wilson, B. Webb, L. Ylinen, E. Verschoor, J. Heeney, G. Towers
- BiologyProceedings of the National Academy of Sciences
- 4 March 2008
It is shown that the Old World monkey, rhesus macaque, also encodes a TRIMCyp protein that has arisen independently from that in owl monkeys, and the lack of activity against HIV-1 suggests that Mamu7 homozygous animals will be null for TRIM5-mediated restriction of HIV- 1 and could contribute to improved animal models for HIV/AIDS.
Fundamental properties of the mammalian innate immune system revealed by multispecies comparison of type I interferon responses
- A. Shaw, J. Hughes, M. Palmarini
- BiologyPLoS Biology
- 1 December 2017
It is shown that gene expansion contributes to the evolution of the IFN system and that interferomes are shaped by lineage-specific pressures, and an analysis of genes commonly down-regulated by IFN suggests that epigenetic regulation of transcription is a fundamental aspect of theIFN response.
Host and Viral Determinants of Mx2 Antiretroviral Activity
- I. Busnadiego, M. Kane, Sam J. Wilson
- BiologyJournal of Virology
- 23 April 2014
ABSTRACT Myxovirus resistance 2 (Mx2/MxB) has recently been uncovered as an effector of the anti-HIV-1 activity of type I interferons (IFNs) that inhibits HIV-1 at an early stage postinfection, after…
A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
- Meike Dittmann, H. Hoffmann, C. Rice
- BiologyCell
- 12 February 2015
The RING-CH Ligase K5 Antagonizes Restriction of KSHV and HIV-1 Particle Release by Mediating Ubiquitin-Dependent Endosomal Degradation of Tetherin
- C. Pardieu, Raphaël Vigan, S. Neil
- Biology, ChemistryPLoS Pathogens
- 1 April 2010
The results demonstrate that K5 is a mechanistically distinct viral countermeasure to tetherin-mediated restriction, and that herpesvirus particle release is sensitive to this mode of antiviral inhibition.
Improvements to the ARTIC multiplex PCR method for SARS-CoV-2 genome sequencing using nanopore
An updated primer scheme with 22 additional primers to improve genome coverage and cost savings which bring the reagent cost down to £10 per sample making it practical for individual labs to sequence thousands of SARS-CoV-2 genomes to support national and international genomic epidemiology efforts.
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