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Dimethyl fumarate (DMF) depletes intracellular glutathione (GSH) by covalent bond formation in a reaction mediated by GSH-S-transferase. Treatment of hypoxic Chinese hamster V79 cells with 5 mM DMF before irradiation radiosensitizes the cells, resulting in an enhancement ratio (ER) of about 2.7 with minimal toxicity, when the end point is clonogenic cell(More)
The effects of polyamines on the loss of biological activity of bacterial transforming DNA irradiated in the absence and presence of sulphydryl-containing compounds has been investigated. In both oxygenated and hypoxic conditions the polyamines (spermine, spermidine, putrescine and cadaverine) are radioprotectors with the degree of protection increasing(More)
Held et al. (1984a,b) demonstrated previously that glutathione (GSH), a negatively charged thiol, is significantly less efficient in the hydrogen atom donation repair reaction with radicals induced by radiation in transforming DNA (t-DNA) than are other thiol compounds. Fahey et al. (1991a,b) postulated that the charge on thiols can influence their ability(More)
OBJECTIVE To compare the effect of the pulpotomy medicaments glutaraldehyde, ferric sulfate, and formocresol on the structure and shear bond strength of a self-etch adhesive to the dentin of primary teeth. METHOD AND MATERIALS Forty human primary molars were sectioned mesiodistally and divided into four groups: group I (control group), dentin specimens(More)
In certain polytherapy programs, ketoconazole can be administered with some antacids that could modify its dissolution rate and reduce its absorption leading to therapeutic failures. The aim of this work was to evaluate the influence of some excipients on this interaction in vitro. In this way, six formulations of directly compressible ketoconazole tablets(More)
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