Salvatore Buono

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PURPOSE This study was to evaluate the efficacy and safety of topiramate (TPM) in refractory partial epilepsy in children, adolescents and young adults. METHODS We performed a prospective open label add-on study in 55 patients (age 2-30 years, mean 15 years) with refractory partial seizures. Topiramate was added to one or two other baseline drugs and the(More)
PURPOSE evaluate the psychomotor evolution of a child with Multiple acyl-CoA dehydrogenase deficiency after treatment with L-carnitine, ubiquinone and riboflavin. METHODS an assessment of psychomotor development was performed before the start of farmacological treatment using the Assessment Scale of Mental Development Griffiths (GMDS-R, 0-2 years). The(More)
The EEG findings in 40 shunted hydrocephalic patients tested after the onset of epileptic seizures are assessed. The salient point to emerge from the study is the higher frequency of anomalies, both specific (spikes, slow spikes, spike and wave complexes) and nonspecific (monomorphic and polymorphic slow waves) on the shunted hemisphere (19 cases) than on(More)
We describe, to our knowledge, the first case of arterial ischemic stroke after primary herpes simplex virus type 1 (HSV1) infection in a previously healthy child, without signs of encephalitis. A 10-year-old previously healthy girl was admitted to our hospital with acute left-sided hemiparesis which involved the lower half of her face. Submandibular(More)
Tracheal surgery requires continued innovation to manage the anesthetic during an open airway phase. A common approach is apneic oxygenation with continuous oxygen flow, but the lack of effective ventilation causes hypercapnia, with respiratory acidosis. We used extracorporeal carbon dioxide removal for intraoperative decapneization during apneic(More)
PURPOSE Mutations in the voltage-gated sodium channel subunit gene SCN1A have been associated with febrile seizures (FSs) in autosomal dominant generalized epilepsy with febrile seizures plus (GEFS+) families and severe myoclonic epilepsy of infancy. The present study assessed the role of SCN1A in familial typical FSs. METHODS FS families were selected(More)
INTRODUCTION We present the case of a patient with dilatative cardiomyopathy waiting for heart transplantation with pleural effusion to be subjected to pleural biopsy, treated with preoperative infusion of levosimendan to improve heart performances. PRESENTATION OF CASE A 56-year-old man (BMI 22,49) with dilatative cardiomyopathy (EF 18%) presented right(More)
The authors reviewed the electroencephalographic findings relevant to a casuistry of 136 cerebral tumours in paediatric age and correlated them with the anatomic site of the neoplasias, as checked on the operating table, and with clinical symptomatology. The casuistry, as concerns the site of the tumours, consists of 32 cases with a hemispheric(More)