Salomez Romain

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The runt-related transcriptional factor RUNX2 is an essential mediator of the osteoblast phenotype and plays a pivotal role in the process of osteoblast differentiation. The involvement of RUNX2 includes the regulation of genes that are important in committing cells to the osteoblast lineage. Increasing evidences are consistent with a requirement of RUNX2(More)
Proteases play a central role in tissue repair and in the process of tumour growth and invasiveness. However, almost all of the proteolytic enzymes are secreted as inactive pro-proteases. With the exception of cathepsin D, which is capable of auto-activation, all the other proteases are activated by a common mechanism involving plasmin, which is itself(More)
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