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  • Wendy C. Moore, Deborah A. Meyers, +19 authors Eugene Bleecker
  • Medicine
  • American journal of respiratory and critical care…
  • 2010 (First Publication: 15 February 2010)
  • RATIONALE The Severe Asthma Research Program cohort includes subjects with persistent asthma who have undergone detailed phenotypic characterization. Previous univariate methods compared features ofContinue Reading
  • Helen K Reddel, Donald R. Taylor, +21 authors Sally E. Wenzel
  • Medicine
  • American journal of respiratory and critical care…
  • 2009 (First Publication: 1 July 2009)
  • BACKGROUND The assessment of asthma control is pivotal to the evaluation of treatment response in individuals and in clinical trials. Previously, asthma control, severity, and exacerbations wereContinue Reading
  • Sally E. Wenzel, Lisa Barrie Schwartz, +4 authors Hong Wei Chu
  • Medicine
  • American journal of respiratory and critical care…
  • 1999 (First Publication: 1 September 1999)
  • The mechanisms associated with the development of severe, corticosteroid (CS)-dependent asthma are poorly understood, but likely heterogenous. It was hypothesized that severe asthma could be dividedContinue Reading
  • Sally E. Wenzel, Mario Castro, Jonathan Corren, Jorge Maspero, Ariel Teper
  • Medicine
  • The Lancet
  • 2016 (First Publication: 2 July 2016)
  • BACKGROUND Dupilumab, a fully human anti-interleukin-4 receptor α monoclonal antibody, inhibits interleukin-4 and interleukin-13 signalling, key drivers of type-2-mediated inflammation. Adults withContinue Reading
  • Sally E. Wenzel, Darren Wilbraham, R. W. Fuller, Elise Burmeister Getz, Malinda Longphre
  • Medicine
  • The Lancet
  • 2007 (First Publication: 1 October 2007)
  • BACKGROUND Increases in T helper (Th) 2 cytokine concentrations have been seen in atopic asthma, with interleukin 4 and interleukin 13 thought to have a role in the physiological response to allergenContinue Reading