Salim A. Chowdhury

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In the study of complex phenotypes, single gene markers can only provide limited insights into the manifestation of phenotype. To this end, protein-protein interaction (PPI) networks prove useful in the identification of multiple interacting markers. Recent studies show that, when considered together, many proteins that are connected via physical and(More)
The precise molecular etiology of obstructive sleep apnea (OSA) is unknown; however recent research indicates that several interconnected aberrant pathways and molecular abnormalities are contributors to OSA. Identifying the genes and pathways associated with OSA can help to expand our understanding of the risk factors for the disease as well as provide new(More)
Emerging research demonstrates the potential of protein-protein interaction (PPI) networks in uncovering the mechanistic bases of cancers, through identification of interacting proteins that are coordinately dysregulated in tumorigenic and metastatic samples. When used as features for classification, such coordinately dysregulated subnetworks improve(More)
The main goal of systems medicine is to provide predictive models of the patho-physiology of complex diseases as well as define healthy states. The reason is clear--we hope accurate models will ultimately lead to more specific and sensitive markers of disease that will help clinicians better stratify their patient populations and optimize treatment plans.(More)
To determine a molecular basis for prognostic differences in glioblastoma multiforme (GBM), we employed a combinatorial network analysis framework to exhaustively search for molecular patterns in protein-protein interaction (PPI) networks. We identified a dysregulated molecular signature distinguishing short-term (survival<225 days) from long-term(More)
In this supplementary document, we prove two theorems that support the algorithms described in [1] and we present experimental results from systematic study of the performance of Crane when the value of the tuneable parameters are varied. First, in Theorem 1, we provide bound on the score of a state function that can be obtained by extending that state(More)
BACKGROUND In recent years, many algorithms have been developed for network-based analysis of differential gene expression in complex diseases. These algorithms use protein-protein interaction (PPI) networks as an integrative framework and identify subnetworks that are coordinately dysregulated in the phenotype of interest. MOTIVATION While such(More)
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