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Variations in therapeutic efficacy and ADRs in the population are known for many drugs. When individuals are adversely affected by their therapy, it suggests the possibility of a pharmacogenic predisposition. Genetic variants and polymorphism affect the metabolism and sites of action of many agents, and the expression of genetic variations is modified by(More)
Pearl Jane Manson enrolled in the Ontario Medical College for Women in 1904 and graduated with an M.D. degree from the University of Toronto in 1907. She was admitted to the Royal College of Surgeons of England in 1911 and worked at a hospital in England during World War I. On returning to Toronto she held positions both at Toronto General Hospital and(More)
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