• Publications
  • Influence
Anticancer therapeutic potential of soy isoflavone, genistein.
TLDR
Althoughgenistein has many potentially therapeutic actions against cancer, its biphasic bioactivity requires caution in determining therapeutic doses of genistein alone or in combination with chemotherapy, radiation therapy, and/or immunotherapies. Expand
Molecular subgroups of medulloblastoma identification using noninvasive magnetic resonance spectroscopy.
TLDR
Investigation of metabolite concentrations measured by MRS shows that medulloblastomas of Group 3/4 differ metabolically as measured using MRS when compared with SHH molecular subgroups, indicating that MRS is a useful and accurate tool to determine medullOBlastoma molecular sub groups. Expand
Cryosurgical ablation of liver tumors in colon cancer patients increases the serum total ganglioside level and then selectively augments antiganglioside IgM.
TLDR
The results suggest that CSA-induced necrosis might have acted as an adjuvant, because purified gangliosides without exogenous adjuvants even after repeated immunization failed to elicit antibody response. Expand
Gangliosides of organ-confined versus metastatic androgen-receptor-negative prostate cancer.
TLDR
Comparison of the gangliosides associated with normal and neoplastic prostate epithelial cells, organ-confined versus metastatic, and AR-negative versus AR-positive CaP cell lines enabled comparison of the androgen-receptor (AR)-negative cell line, which makes HH870 a potential component of a polyvalent-vaccine for active-specific immunotherapy of CaP. Expand
Abstract 5021: Regulatory T-cells and effects of anti-CTLA4 and anti-PD1 therapy in a transgenic murine model of neuroblastoma
TLDR
The results demonstrate presence of Treg cells in NBL-Tag tumors and provide pre-clinical evidence that Ipilimumab and Nivolumab, recently approved melanoma drugs, may be useful in treating neuroblastoma children with minimal residual disease. Expand
Human Antiganglioside Autoantibodies: Validation of ELISA
TLDR
There is a need to validate the protocol for enzyme‐linked immunosorbent assay (ELISA) of antiganglioside IgM autoantibodies, which must consider the purity of gangliosides from different commercial sources, the coating of gangLiosides onto a solid matrix in a manner that maximizes exposure of oligosaccharide epitopes to IgM paratopes, techniques to minimize background noise and eliminate nonspecific antibody binding. Expand
Differential Growth Suppression of Human Melanoma Cells by Tea (Camellia sinensis) Epicatechins (ECG, EGC and EGCG)
TLDR
The hypothesis that anticancer action of the various catechins may vary with the type of malignancy is validated and provides a model for tumor cell heterogeneity based on susceptibility and resistance of tumor cells to different green tea catechINS is provided. Expand
Tumor-associated macrophages promote neuroblastoma via STAT3 phosphorylation and up-regulation of c-MYC
TLDR
A novel role of TAMs as inducers of MYC expression in neuroblastomas lacking independent oncogene activation is indicated, and the role of IL-6-independent activation of STAT3 is underscored in this mechanism. Expand
Endogenous immune response to gangliosides in patients with confined prostate cancer
Our study investigated whether endogenous IgM antibodies to gangliosides occur in patients with early stages of prostate cancer (CaP) patients, after defining ganglioside profiles of CaP cell lines.Expand
Increased levels of gangliosides in the plasma and ascitic fluid of patients with advanced ovarian cancer
TLDR
Assessment of the expression of total gangliosides in primary ovarian cancer cell lines, ascitic fluid and plasma of advanced ovarian cancer patients finds no significant differences between cell lines and patients with and without cancer. Expand
...
1
2
3
...