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Paenilarvins: Iturin Family Lipopeptides from the Honey Bee Pathogen Paenibacillus larvae
Paenilarvins are the first antifungal secondary metabolites to be identified from P. larvae, which are iturinic lipopeptides exhibiting strong antIfungal activities, obtained by bioassay‐guided fractionation from cultures of P. larva.
Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation
Both binding affinity assays and docking studies of the CYP121A1 inhibitors suggest type II indirect binding through interstitial water molecules, with key binding residues Thr77, Val78, Val82, Val83, Met86, Ser237, Gln385, and Arg386 comparable with the binding interactions observed with fluconazole and the natural substrate dicyclotyrosine.
Pyrronazols, metabolites from the myxobacteria Nannocystis pusilla and N. exedens, are unusual chlorinated pyrone-oxazole-pyrroles.
HRESIMS, NMR, and X-ray crystallographic analysis was used in the structure elucidation including the absolute configuration of pyrronazol A (1), which showed no significant cytotoxicity and 6 showed weak antibacterial and antifungal activity against some of the strains tested.
Nannozinones and sorazinones, unprecedented pyrazinones from myxobacteria.
The structures of nannozinones A and B were discovered as unusual dihydropyrrolo- and pyrrolopyrazinone derivatives, while sorazinone A was characterized as an aromatic diketopiperazine and soraz inones 5 and 6 did not show any significant cytotoxicity and only weak activity against the Gram-positive Nocardia sp.
Design and Synthesis of Imidazole and Triazole Pyrazoles as Mycobacterium Tuberculosis CYP121A1 Inhibitors
Three series of azole pyrazole derivatives were designed through two synthetic pathways and spectroscopic data showed that all the synthesised compounds produced a type II red shift of the heme Soret band indicating either direct binding to heme iron or putative indirect binding via an interstitial water molecule.
Aggregicoccus edonensis gen. nov., sp. nov., an unusually aggregating myxobacterium isolated from a soil sample.
A novel genus and species is proposed, Aggregicoccus edonensis gen. nov., for strains MCy1366(T) and MCy10622, which showed a chemoheterotrophic mode of nutrition and some morphological features like fruiting-body-like aggregates were barely reproducible in the type strain.
Paenilarvins: Iturin Family Lipopeptides from the Honey Bee Pathogen Paenibacillus larvae.
Isolation and structure elucidation of three novel iturin-type lipopeptides, paenilarvins A-C, are described.
Edonamides, the First Secondary Metabolites from the Recently Described Myxobacterium Aggregicoccus edonensis.
The two isolated fatty acid styryl amides, endonamides A (Ia) and B (Ib), do not show inhibitory activity against different bacteria, fungi, and cell lines.