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The effects of adrenoceptor agonists and antagonists on the contractile activity of cervical strips from early pregnant and nonpregnant women were studied. Noradrenaline and the alpha-adrenoceptor agonist, phenylephrine, had a stimulatory effect on smooth muscle activity. This response could be blocked totally by the alpha-adrenoceptor antagonist,(More)
BACKGROUND Pulmonary arterial hypertension is a severe and progressive disease, a hallmark of which is pulmonary vascular remodeling. Nicotinamide phosphoribosyltransferase (NAMPT) is a cytozyme that regulates intracellular nicotinamide adenine dinucleotide levels and cellular redox state, regulates histone deacetylases, promotes cell proliferation, and(More)
2) CHRISTOPFIERSEN, J . , U. I~. P R E C H T : B io l . Z e n t r . 69, 2 4 0 (1950). ~) C~IRISTOPHGRSEN, J. : Arch. MikrobioL 45, 58 (1963). 4) RINO, K., u. J. CHRISmOPHERS~N: Arch. Mikrobiol. 48, 50 (I964). . a) RAo, K.P. : Int. Symp. on Cytoeeology, Leningrad ~963 (ira Druek). 6)HOC;4aCHa, P.W.: Gen. Comp. EndoerinoI. 2, 499 ( 1 9 6 2 ) . ~) ]gKBERG D.(More)
Five pairs of median and 1 pair of lateral neurosecretory cell groups occur in the protocerebrum ofDysdercus koenigii, a hemipteran pest on the ladies finger plant (Hibiscus esculentus). The lateral neurosecretory cells (LNSC) become active prior to, and at the time of commencement of mating and release their secretion within 24 h of commencement. The(More)
5 pairs of median and 1 pair of lateral neurosecretory cell groups occur in the protocerebrum of maleDysdercus koenigii, a hemipteran pest on Hibiscus esculentus. The lateral neurosecretory cells (LNSC) are in a state of peak activity when the male engages itself in copulation. 24 h later, the LNSC are found to be inactive, but they again resume their(More)
The influence of purified porcine relaxin on contractility of human cervical smooth muscle was investigated in vitro. Strips of cervical tissue were obtained by needle biopsy from pregnant and nonpregnant women and were mounted in a superfused organ chamber for isometric measurement of contractile activity. Relaxin (0.005-25 micrograms/ml) inhibited the(More)
The contractile activity of smooth muscle from the pregnant and nonpregnant human cervix uteri was studied in organ bath experiments. Several patterns of spontaneous activity with varying frequency and amplitude were observed. Prostaglandin E2 inhibited muscle activity in a concentration-dependent manner, and total inhibition was achieved in pregnant tissue(More)