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Protein synthesis is a dynamic process that tunes the cellular proteome in response to internal and external demands. Metabolic labeling approaches identify the general proteomic response but cannot visualize specific newly synthesized proteins within cells. Here we describe a technique that couples noncanonical amino acid tagging or puromycylation with the(More)
Cadherins, Ca(2+)-dependent adhesion molecules, are crucial for cell-cell junctions and remodeling. Cadherins form inter-junctional lattices by the formation of both cis and trans dimers. Here, we directly visualize and quantify the spatiotemporal dynamics of wild-type and dimer mutant N-cadherin interactions using time-lapse imaging of junction assembly,(More)
BACKGROUND The purpose of this study was to investigate the perceptions toward the profession, the level of explicit self-esteem (ESE) of Indian students pursuing the course of dental hygienists, to evaluate the relationship between the two and to develop educational strategies to positively influence students' perceptions. We also wished to evaluate the(More)
In this paper, we present an approach for edge detection using adaptive thresholding and Ant Colony Optimization (ACO) algorithm to obtain a well-connected image edge map. Initially, the edge map of the image is obtained using adaptive thresholding. The end points obtained using adaptive threshoding are calculated and the ants are placed at these points.(More)
N-glycosylation - the sequential addition of complex sugars to adhesion proteins, neurotransmitter receptors, ion channels and secreted trophic factors as they progress through the endoplasmic reticulum and the Golgi apparatus - is one of the most frequent protein modifications. In mammals, most organ-specific N-glycosylation events occur in the brain. Yet,(More)
One Sentence Summary: Hundreds of key neuronal membrane proteins display atypical N-11 glycosylation profiles typically associated with nascent intracellular proteins in the early secretory 12 pathway, which may shorten their lifetime and modulate synaptic signaling. 13 14 Abstract 15 N-glycosylation – the sequential addition of complex sugars to adhesion(More)
INTRODUCTION Oral health problems, especially dental caries are known to be common in children with severe heart disease, especially at early ages. The role of nitric oxide (NO) in protection against oral diseases owing to its strong antimicrobial action has been a topic of interest. OBJECTIVE The current study was carried out to estimate the NO levels in(More)
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