Saki Maeda-Otsuka

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S-1, a 5-fluorouracil (5-FU)-based anti-cancer agent, is an important drug for treating metastatic extramammary Paget's disease (EMPD). Although intratumor expression levels of 5-FU metabolism enzymes have been studied widely in many solid tumors, no studies have examined on the expression levels of thymidylate synthase (TS), orotate(More)
Dear Editor, Biologics rarely induce interstitial lung disease. Among biological agents, anti-interleukin (IL)-17 antibody generally ameliorates fibrotic conditions. We experienced a case of interstitial pneumonia in a patient with psoriasis vulgaris treated with secukinumab. A 36-year-old man had an 11-year history of severe psoriasis vulgaris (without(More)
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